GO Annotations Graph

• Symbol: Dot1l
• Name: DOT1 like histone lysine methyltransferase
• ID: MGI:2143886

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0031151	histone H3K79 methyltransferase activity	IBA	J:265628
Molecular Function	GO:0140956	histone H3K79 trimethyltransferase activity	IEA	J:72245
Molecular Function	GO:0042054	histone methyltransferase activity	ISO	J:164563
Molecular Function	GO:0042054	histone methyltransferase activity	IDA	J:87894
Molecular Function	GO:0042054	histone methyltransferase activity	ISO	J:98959
Molecular Function	GO:0003676	nucleic acid binding	ISO	J:164563
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0003713	transcription coactivator activity	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:160934
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:160934
Cellular Component	GO:0005634	nucleus	ISO	J:98959
Cellular Component	GO:0032991	protein-containing complex	ISO	J:98959
Biological Process	GO:0000077	DNA damage checkpoint signaling	IBA	J:265628
Biological Process	GO:0006281	DNA repair	IBA	J:265628
Biological Process	GO:0010467	gene expression	IMP	J:160934
Biological Process	GO:0010467	gene expression	IDA	J:160934
Biological Process	GO:0034729	histone H3-K79 methylation	ISO	J:98959
Biological Process	GO:0034729	histone H3-K79 methylation	ISO	J:98959
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:98959
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:98959
Biological Process	GO:0046425	regulation of receptor signaling pathway via JAK-STAT	ISO	J:164563
Biological Process	GO:2000677	regulation of transcription regulatory region DNA binding	ISO	J:164563
Biological Process	GO:2000677	regulation of transcription regulatory region DNA binding	IBA	J:265628