GO Annotations Graph

• Symbol: Inca1
• Name: inhibitor of CDK, cyclin A1 interacting protein 1
• ID: MGI:2144284

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0030332	cyclin binding	IBA	J:265628
Molecular Function	GO:0030332	cyclin binding	ISO	J:73065
Molecular Function	GO:0030332	cyclin binding	IDA	J:175667
Molecular Function	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	IBA	J:265628
Molecular Function	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	ISO	J:73065
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:175667
Molecular Function	GO:0004860	protein kinase inhibitor activity	IEA	J:60000
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0016604	nuclear body	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Biological Process	GO:0097190	apoptotic signaling pathway	IGI	J:175810
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0048144	fibroblast proliferation	IMP	J:175810
Biological Process	GO:0048144	fibroblast proliferation	IGI	J:175810
Biological Process	GO:0008285	negative regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:0008285	negative regulation of cell population proliferation	IDA	J:175667
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	IBA	J:265628
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	ISO	J:73065
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	IMP	J:175667
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	IMP	J:175810
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	IGI	J:175810
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	IGI	J:175810