GO Annotations Graph

• Symbol: Akr1c18
• Name: aldo-keto reductase family 1, member C18
• ID: MGI:2145420

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0047020	15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity	ISO	J:164563
Molecular Function	GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	ISO	J:155856
Molecular Function	GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	IDA	J:95560
Molecular Function	GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	ISO	J:73065
Molecular Function	GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	IMP	J:95560
Molecular Function	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	ISO	J:164563
Molecular Function	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	ISO	J:155856
Molecular Function	GO:0004032	alditol:NADP+ 1-oxidoreductase activity	IBA	J:265628
Molecular Function	GO:0004033	aldo-keto reductase (NADP) activity	ISO	J:164563
Molecular Function	GO:0004033	aldo-keto reductase (NADP) activity	ISO	J:155856
Molecular Function	GO:0047023	androsterone dehydrogenase activity	ISO	J:164563
Molecular Function	GO:0047023	androsterone dehydrogenase activity	IBA	J:265628
Molecular Function	GO:0032052	bile acid binding	IBA	J:265628
Molecular Function	GO:0047787	delta4-3-oxosteroid 5beta-reductase activity	ISO	J:164563
Molecular Function	GO:0035410	dihydrotestosterone 17-beta-dehydrogenase activity	ISO	J:164563
Molecular Function	GO:0045550	geranylgeranyl reductase activity	ISO	J:164563
Molecular Function	GO:0045703	ketoreductase activity	ISO	J:164563
Molecular Function	GO:0047086	ketosteroid monooxygenase activity	ISO	J:164563
Molecular Function	GO:0047086	ketosteroid monooxygenase activity	IBA	J:265628
Molecular Function	GO:0004745	NAD-retinol dehydrogenase activity	ISO	J:164563
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:72247
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	ISO	J:164563
Molecular Function	GO:0018636	phenanthrene 9,10-monooxygenase activity	ISO	J:164563
Molecular Function	GO:0001758	retinal dehydrogenase activity	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:73065
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	ISO	J:155856
Biological Process	GO:0044597	daunorubicin metabolic process	IBA	J:265628
Biological Process	GO:0044598	doxorubicin metabolic process	IBA	J:265628
Biological Process	GO:0007567	parturition	IMP	J:95560
Biological Process	GO:0006709	progesterone catabolic process	IMP	J:95560
Biological Process	GO:0006709	progesterone catabolic process	IMP	J:95560
Biological Process	GO:0006709	progesterone catabolic process	IDA	J:95560
Biological Process	GO:0006709	progesterone catabolic process	IMP	J:95560
Biological Process	GO:0042448	progesterone metabolic process	ISO	J:155856
Biological Process	GO:0042448	progesterone metabolic process	IBA	J:265628
Biological Process	GO:0042448	progesterone metabolic process	ISO	J:73065
Biological Process	GO:0006693	prostaglandin metabolic process	IBA	J:265628
Biological Process	GO:0050810	regulation of steroid biosynthetic process	ISO	J:155856