GO Annotations Graph

• Symbol: Prkaa1
• Name: protein kinase, AMP-activated, alpha 1 catalytic subunit
• ID: MGI:2145955

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0050405	[acetyl-CoA carboxylase] kinase activity	IEA	J:72245
Molecular Function	GO:0047322	[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity	IEA	J:72245
Molecular Function	GO:0004679	AMP-activated protein kinase activity	ISO	J:155856
Molecular Function	GO:0004679	AMP-activated protein kinase activity	IDA	J:175186
Molecular Function	GO:0004679	AMP-activated protein kinase activity	IGI	J:259120
Molecular Function	GO:0004679	AMP-activated protein kinase activity	IDA	J:175316
Molecular Function	GO:0004679	AMP-activated protein kinase activity	IDA	J:153754
Molecular Function	GO:0004679	AMP-activated protein kinase activity	IMP	J:104202
Molecular Function	GO:0004679	AMP-activated protein kinase activity	IDA	J:172248
Molecular Function	GO:0004679	AMP-activated protein kinase activity	IGI	J:259116
Molecular Function	GO:0004679	AMP-activated protein kinase activity	IDA	J:136666
Molecular Function	GO:0004679	AMP-activated protein kinase activity	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0003682	chromatin binding	IDA	J:163548
Molecular Function	GO:0004869	cysteine-type endopeptidase inhibitor activity	ISO	J:164563
Molecular Function	GO:0140823	histone H2BS36 kinase activity	IDA	J:297184
Molecular Function	GO:0140823	histone H2BS36 kinase activity	IDA	J:163548
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0019900	kinase binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0140677	molecular function activator activity	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:172248
Molecular Function	GO:0005515	protein binding	IPI	J:175316
Molecular Function	GO:0005515	protein binding	IPI	J:175186
Molecular Function	GO:0005515	protein binding	IPI	J:245317
Molecular Function	GO:0005515	protein binding	IPI	J:153754
Molecular Function	GO:0005515	protein binding	IPI	J:208272
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:319691
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:155856
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0050321	tau-protein kinase activity	IEA	J:72245
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0030424	axon	IGI	J:259120
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0000785	chromatin	IDA	J:297184
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:176978
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:133330
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0030425	dendrite	IGI	J:259120
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	IGI	J:259120
Cellular Component	GO:0016607	nuclear speck	ISO	J:164563
Cellular Component	GO:0031588	nucleotide-activated protein kinase complex	ISO	J:155856
Cellular Component	GO:0031588	nucleotide-activated protein kinase complex	ISO	J:164563
Cellular Component	GO:0031588	nucleotide-activated protein kinase complex	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:153754
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Biological Process	GO:0006914	autophagy	IEA	J:60000
Biological Process	GO:0061762	CAMKK-AMPK signaling cascade	ISO	J:164563
Biological Process	GO:0071277	cellular response to calcium ion	ISO	J:155856
Biological Process	GO:0071277	cellular response to calcium ion	IGI	J:259120
Biological Process	GO:0042149	cellular response to glucose starvation	ISO	J:164563
Biological Process	GO:0042149	cellular response to glucose starvation	IDA	J:175316
Biological Process	GO:0042149	cellular response to glucose starvation	IDA	J:319691
Biological Process	GO:0042149	cellular response to glucose starvation	IBA	J:265628
Biological Process	GO:0071333	cellular response to glucose stimulus	ISO	J:155856
Biological Process	GO:0071333	cellular response to glucose stimulus	IGI	J:259120
Biological Process	GO:0031669	cellular response to nutrient levels	IDA	J:175316
Biological Process	GO:0031669	cellular response to nutrient levels	ISO	J:164563
Biological Process	GO:0034599	cellular response to oxidative stress	IGI	J:259116
Biological Process	GO:0071380	cellular response to prostaglandin E stimulus	IGI	J:194901
Biological Process	GO:0006695	cholesterol biosynthetic process	IEA	J:60000
Biological Process	GO:0008203	cholesterol metabolic process	IEA	J:60000
Biological Process	GO:0006325	chromatin organization	IEA	J:60000
Biological Process	GO:0009631	cold acclimation	ISO	J:155856
Biological Process	GO:0097009	energy homeostasis	ISO	J:155856
Biological Process	GO:0006633	fatty acid biosynthetic process	IEA	J:60000
Biological Process	GO:0055089	fatty acid homeostasis	ISO	J:155856
Biological Process	GO:0006631	fatty acid metabolic process	IEA	J:60000
Biological Process	GO:0019395	fatty acid oxidation	IMP	J:90488
Biological Process	GO:0042593	glucose homeostasis	IMP	J:104202
Biological Process	GO:0006006	glucose metabolic process	IMP	J:90488
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0008610	lipid biosynthetic process	IDA	J:172248
Biological Process	GO:1905691	lipid droplet disassembly	ISO	J:164563
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0061744	motor behavior	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:136666
Biological Process	GO:0010629	negative regulation of gene expression	IGI	J:259116
Biological Process	GO:1903944	negative regulation of hepatocyte apoptotic process	ISO	J:164563
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	ISO	J:155856
Biological Process	GO:0050995	negative regulation of lipid catabolic process	IDA	J:175186
Biological Process	GO:0032007	negative regulation of TOR signaling	IMP	J:136666
Biological Process	GO:0032007	negative regulation of TOR signaling	IBA	J:265628
Biological Process	GO:1904428	negative regulation of tubulin deacetylation	IGI	J:259116
Biological Process	GO:0070050	neuron cellular homeostasis	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:1904179	positive regulation of adipose tissue development	IDA	J:297184
Biological Process	GO:0010508	positive regulation of autophagy	IMP	J:175316
Biological Process	GO:0010508	positive regulation of autophagy	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:163548
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:210206
Biological Process	GO:0045821	positive regulation of glycolytic process	ISO	J:155856
Biological Process	GO:1903109	positive regulation of mitochondrial transcription	IMP	J:257325
Biological Process	GO:2000758	positive regulation of peptidyl-lysine acetylation	IGI	J:259116
Biological Process	GO:1903829	positive regulation of protein localization	IGI	J:259116
Biological Process	GO:1903955	positive regulation of protein targeting to mitochondrion	IMP	J:257325
Biological Process	GO:0048643	positive regulation of skeletal muscle tissue development	IMP	J:210206
Biological Process	GO:1990044	protein localization to lipid droplet	IDA	J:319691
Biological Process	GO:1990044	protein localization to lipid droplet	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0042752	regulation of circadian rhythm	IMP	J:153754
Biological Process	GO:0070507	regulation of microtubule cytoskeleton organization	IGI	J:259116
Biological Process	GO:0033135	regulation of peptidyl-serine phosphorylation	IMP	J:210206
Biological Process	GO:0062028	regulation of stress granule assembly	IGI	J:259116
Biological Process	GO:0060627	regulation of vesicle-mediated transport	ISO	J:155856
Biological Process	GO:0014823	response to activity	ISO	J:155856
Biological Process	GO:0031000	response to caffeine	ISO	J:155856
Biological Process	GO:1901563	response to camptothecin	IMP	J:163548
Biological Process	GO:0010332	response to gamma radiation	IMP	J:163548
Biological Process	GO:0042542	response to hydrogen peroxide	IMP	J:163548
Biological Process	GO:0009411	response to UV	IMP	J:163548
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0006694	steroid biosynthetic process	IEA	J:60000
Biological Process	GO:0008202	steroid metabolic process	IEA	J:60000
Biological Process	GO:0016126	sterol biosynthetic process	IEA	J:60000
Biological Process	GO:0016055	Wnt signaling pathway	IEA	J:60000