GO Annotations Graph

• Symbol: Adamts12
• Name: ADAM metallopeptidase with thrombospondin type 1 motif 12
• ID: MGI:2146046

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004222	metalloendopeptidase activity	ISO	J:164563
Molecular Function	GO:0004222	metalloendopeptidase activity	IBA	J:265628
Molecular Function	GO:0008237	metallopeptidase activity	IEA	J:60000
Molecular Function	GO:0008237	metallopeptidase activity	IEA	J:72247
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Cellular Component	GO:0031012	extracellular matrix	IBA	J:265628
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Biological Process	GO:0016477	cell migration	ISO	J:164563
Biological Process	GO:0007160	cell-matrix adhesion	ISO	J:164563
Biological Process	GO:0071773	cellular response to BMP stimulus	ISO	J:164563
Biological Process	GO:0071347	cellular response to interleukin-1	ISO	J:164563
Biological Process	GO:0071356	cellular response to tumor necrosis factor	ISO	J:164563
Biological Process	GO:0002062	chondrocyte differentiation	IGI	J:264139
Biological Process	GO:0030199	collagen fibril organization	IGI	J:264139
Biological Process	GO:0030199	collagen fibril organization	IGI	J:264139
Biological Process	GO:0030198	extracellular matrix organization	IBA	J:265628
Biological Process	GO:2001113	negative regulation of cellular response to hepatocyte growth factor stimulus	ISO	J:164563
Biological Process	GO:1902548	negative regulation of cellular response to vascular endothelial growth factor stimulus	ISO	J:164563
Biological Process	GO:0032331	negative regulation of chondrocyte differentiation	ISO	J:164563
Biological Process	GO:1902203	negative regulation of hepatocyte growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0001503	ossification	IGI	J:264139
Biological Process	GO:0043931	ossification involved in bone maturation	IGI	J:264139
Biological Process	GO:0043931	ossification involved in bone maturation	IGI	J:264139
Biological Process	GO:0043931	ossification involved in bone maturation	IGI	J:264139
Biological Process	GO:0043931	ossification involved in bone maturation	IGI	J:264139
Biological Process	GO:0030167	proteoglycan catabolic process	ISO	J:164563
Biological Process	GO:0006029	proteoglycan metabolic process	IGI	J:264139
Biological Process	GO:0006508	proteolysis	IBA	J:265628
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	ISO	J:164563
Biological Process	GO:1901509	regulation of endothelial tube morphogenesis	ISO	J:164563
Biological Process	GO:0050727	regulation of inflammatory response	ISO	J:164563