GO Annotations Graph

• Symbol: Fbxo4
• Name: F-box protein 4
• ID: MGI:2146220

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005515	protein binding	IPI	J:175317
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	ISO	J:164563
Molecular Function	GO:1990756	ubiquitin ligase-substrate adaptor activity	IDA	J:255973
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IDA	J:178645
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	ISO	J:164563
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	IBA	J:265628
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	IDA	J:178645
Cellular Component	GO:0000151	ubiquitin ligase complex	ISO	J:164563
Biological Process	GO:0019725	cellular homeostasis	IMP	J:178645
Biological Process	GO:0071479	cellular response to ionizing radiation	IDA	J:178645
Biological Process	GO:0090398	cellular senescence	IMP	J:178645
Biological Process	GO:0035726	common myeloid progenitor cell proliferation	IMP	J:178645
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	IMP	J:178645
Biological Process	GO:1900181	negative regulation of protein localization to nucleus	IMP	J:178645
Biological Process	GO:1902916	positive regulation of protein polyubiquitination	IMP	J:178645
Biological Process	GO:0031398	positive regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:0031398	positive regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:0032212	positive regulation of telomere maintenance via telomerase	ISO	J:164563
Biological Process	GO:0010608	post-transcriptional regulation of gene expression	IMP	J:178645
Biological Process	GO:0031648	protein destabilization	IMP	J:178645
Biological Process	GO:0000209	protein polyubiquitination	ISO	J:164563
Biological Process	GO:0000209	protein polyubiquitination	ISO	J:164563
Biological Process	GO:0000209	protein polyubiquitination	IBA	J:265628
Biological Process	GO:0016567	protein ubiquitination	ISO	J:164563
Biological Process	GO:2000001	regulation of DNA damage checkpoint	IMP	J:178645
Biological Process	GO:0031647	regulation of protein stability	ISO	J:164563
Biological Process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA	J:265628
Biological Process	GO:0000723	telomere maintenance	ISO	J:164563
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	ISO	J:164563