GO Annotations Graph

• Symbol: Hrg
• Name: histidine-rich glycoprotein
• ID: MGI:2146636

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004869	cysteine-type endopeptidase inhibitor activity	IEA	J:72247
Molecular Function	GO:0020037	heme binding	ISO	J:164563
Molecular Function	GO:0043395	heparan sulfate proteoglycan binding	ISO	J:164563
Molecular Function	GO:0008201	heparin binding	ISO	J:164563
Molecular Function	GO:0008201	heparin binding	IBA	J:265628
Molecular Function	GO:0019865	immunoglobulin binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:96478
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	IBA	J:265628
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	IMP	J:134621
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	IBA	J:265628
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265607
Cellular Component	GO:0036019	endolysosome	IBA	J:265628
Cellular Component	GO:0036019	endolysosome	IDA	J:203507
Cellular Component	GO:0005576	extracellular region	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IBA	J:265628
Cellular Component	GO:0061474	phagolysosome membrane	IDA	J:203507
Cellular Component	GO:0031982	vesicle	IDA	J:203507
Biological Process	GO:0001525	angiogenesis	IEA	J:60000
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	IMP	J:177146
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	ISO	J:164563
Biological Process	GO:0007596	blood coagulation	IEA	J:60000
Biological Process	GO:0006935	chemotaxis	IEA	J:60000
Biological Process	GO:0051838	cytolysis by host of symbiont cells	ISO	J:164563
Biological Process	GO:0050832	defense response to fungus	IMP	J:177146
Biological Process	GO:0050832	defense response to fungus	ISO	J:164563
Biological Process	GO:0042730	fibrinolysis	IMP	J:134621
Biological Process	GO:0097037	heme export	IMP	J:203507
Biological Process	GO:0015886	heme transport	IBA	J:265628
Biological Process	GO:0015886	heme transport	ISO	J:203507
Biological Process	GO:0015886	heme transport	IMP	J:203507
Biological Process	GO:0007599	hemostasis	IEA	J:60000
Biological Process	GO:0016525	negative regulation of angiogenesis	IMP	J:185006
Biological Process	GO:0016525	negative regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0043537	negative regulation of blood vessel endothelial cell migration	IMP	J:185006
Biological Process	GO:0007162	negative regulation of cell adhesion	ISO	J:164563
Biological Process	GO:0033629	negative regulation of cell adhesion mediated by integrin	ISO	J:164563
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:164563
Biological Process	GO:0030308	negative regulation of cell growth	IDA	J:185006
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0010951	negative regulation of endopeptidase activity	IBA	J:265628
Biological Process	GO:2001027	negative regulation of endothelial cell chemotaxis	ISO	J:164563
Biological Process	GO:0051918	negative regulation of fibrinolysis	IBA	J:265628
Biological Process	GO:0051918	negative regulation of fibrinolysis	IMP	J:134621
Biological Process	GO:0010593	negative regulation of lamellipodium assembly	ISO	J:164563
Biological Process	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway	ISO	J:164563
Biological Process	GO:0030168	platelet activation	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:2000504	positive regulation of blood vessel remodeling	IMP	J:185006
Biological Process	GO:2000504	positive regulation of blood vessel remodeling	ISO	J:164563
Biological Process	GO:0051894	positive regulation of focal adhesion assembly	ISO	J:164563
Biological Process	GO:0002839	positive regulation of immune response to tumor cell	ISO	J:164563
Biological Process	GO:0002839	positive regulation of immune response to tumor cell	IMP	J:185006
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	ISO	J:164563
Biological Process	GO:0030193	regulation of blood coagulation	IMP	J:134621
Biological Process	GO:0030193	regulation of blood coagulation	ISO	J:164563
Biological Process	GO:0010468	regulation of gene expression	IMP	J:185006
Biological Process	GO:0010468	regulation of gene expression	ISO	J:164563
Biological Process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0010543	regulation of platelet activation	IMP	J:134621
Biological Process	GO:0010543	regulation of platelet activation	IMP	J:169468
Biological Process	GO:0010543	regulation of platelet activation	IBA	J:265628
Biological Process	GO:0043254	regulation of protein-containing complex assembly	ISO	J:164563
Biological Process	GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron	IDA	J:203507
Biological Process	GO:0014070	response to organic cyclic compound	IDA	J:203507