GO Annotations Graph

• Symbol: Ticam1
• Name: TIR domain containing adaptor molecule 1
• ID: MGI:2147032

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:162535
Molecular Function	GO:0005515	protein binding	IPI	J:171920
Molecular Function	GO:0005515	protein binding	IPI	J:183537
Molecular Function	GO:0005515	protein binding	IPI	J:169794
Molecular Function	GO:0005515	protein binding	IPI	J:166021
Molecular Function	GO:0005515	protein binding	IPI	J:144594
Molecular Function	GO:0005515	protein binding	IPI	J:245346
Molecular Function	GO:0005515	protein binding	IPI	J:173994
Molecular Function	GO:0005515	protein binding	IPI	J:224712
Molecular Function	GO:0005515	protein binding	IPI	J:152781
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	IBA	J:265628
Molecular Function	GO:0097027	ubiquitin-protein transferase activator activity	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005829	cytosol	IDA	J:173994
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0005768	endosome	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IDA	J:173994
Cellular Component	GO:0097342	ripoptosome	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0097190	apoptotic signaling pathway	IMP	J:84896
Biological Process	GO:0042113	B cell activation	IMP	J:84679
Biological Process	GO:0042100	B cell proliferation	IMP	J:84679
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IMP	J:123633
Biological Process	GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	IMP	J:158401
Biological Process	GO:0032602	chemokine production	IMP	J:84679
Biological Process	GO:0032602	chemokine production	IGI	J:84679
Biological Process	GO:0051607	defense response to virus	IMP	J:84896
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IGI	J:84679
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IMP	J:84679
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:72247
Biological Process	GO:0032608	interferon-beta production	IMP	J:84679
Biological Process	GO:0032608	interferon-beta production	IMP	J:84896
Biological Process	GO:0032635	interleukin-6 production	IMP	J:84679
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IMP	J:84896
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IMP	J:84679
Biological Process	GO:0002281	macrophage activation involved in immune response	IMP	J:84896
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:84679
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:84679
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:84896
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:84896
Biological Process	GO:0010934	macrophage cytokine production	IGI	J:84896
Biological Process	GO:0010934	macrophage cytokine production	IDA	J:84896
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:84679
Biological Process	GO:0002756	MyD88-independent toll-like receptor signaling pathway	IMP	J:84896
Biological Process	GO:0002756	MyD88-independent toll-like receptor signaling pathway	IMP	J:84679
Biological Process	GO:0006809	nitric oxide biosynthetic process	IMP	J:84896
Biological Process	GO:0010508	positive regulation of autophagy	IMP	J:123633
Biological Process	GO:0050871	positive regulation of B cell activation	IMP	J:84679
Biological Process	GO:0030890	positive regulation of B cell proliferation	IMP	J:84679
Biological Process	GO:0032722	positive regulation of chemokine production	IMP	J:84679
Biological Process	GO:0032722	positive regulation of chemokine production	IGI	J:84679
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	IMP	J:158401
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	IBA	J:265628
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:158401
Biological Process	GO:0010628	positive regulation of gene expression	IGI	J:158401
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IMP	J:173994
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IBA	J:265628
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IMP	J:84679
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IGI	J:84679
Biological Process	GO:0032728	positive regulation of interferon-beta production	IMP	J:84679
Biological Process	GO:0032728	positive regulation of interferon-beta production	IMP	J:84896
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:84679
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IGI	J:84896
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:84896
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:84679
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:84679
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IDA	J:84896
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:84679
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:84896
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:84679
Biological Process	GO:0002735	positive regulation of myeloid dendritic cell cytokine production	IMP	J:173994
Biological Process	GO:0002735	positive regulation of myeloid dendritic cell cytokine production	IBA	J:265628
Biological Process	GO:0032816	positive regulation of natural killer cell activation	IBA	J:265628
Biological Process	GO:0032816	positive regulation of natural killer cell activation	IMP	J:177021
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IBA	J:265628
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IGI	J:84679
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IMP	J:84679
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	IMP	J:84896
Biological Process	GO:0032092	positive regulation of protein binding	IDA	J:152781
Biological Process	GO:0031398	positive regulation of protein ubiquitination	IDA	J:152781
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:84896
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IGI	J:84896
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IDA	J:84896
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:84679
Biological Process	GO:0032481	positive regulation of type I interferon production	ISO	J:164563
Biological Process	GO:0032481	positive regulation of type I interferon production	IMP	J:84896
Biological Process	GO:0043254	regulation of protein-containing complex assembly	IMP	J:84896
Biological Process	GO:0043330	response to exogenous dsRNA	IBA	J:265628
Biological Process	GO:0043330	response to exogenous dsRNA	IMP	J:84896
Biological Process	GO:0043330	response to exogenous dsRNA	IMP	J:84679
Biological Process	GO:0043330	response to exogenous dsRNA	ISO	J:170947
Biological Process	GO:0043330	response to exogenous dsRNA	IDA	J:84896
Biological Process	GO:0043330	response to exogenous dsRNA	IMP	J:173994
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:84679
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:84896
Biological Process	GO:0032496	response to lipopolysaccharide	IGI	J:84896
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:84679
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0002224	toll-like receptor signaling pathway	ISO	J:164563
Biological Process	GO:0035666	TRIF-dependent toll-like receptor signaling pathway	ISO	J:164563
Biological Process	GO:0035666	TRIF-dependent toll-like receptor signaling pathway	IMP	J:123633
Biological Process	GO:0035666	TRIF-dependent toll-like receptor signaling pathway	IBA	J:265628
Biological Process	GO:0032640	tumor necrosis factor production	IDA	J:84896
Biological Process	GO:0032640	tumor necrosis factor production	IMP	J:84896
Biological Process	GO:0032640	tumor necrosis factor production	IMP	J:84679
Biological Process	GO:0032640	tumor necrosis factor production	IGI	J:84896
Biological Process	GO:0032606	type I interferon production	IMP	J:84896