GO Annotations Graph

• Symbol: Me2
• Name: malic enzyme 2, NAD(+)-dependent, mitochondrial
• ID: MGI:2147351

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003824	catalytic activity	IEA	J:60000
Molecular Function	GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity	IDA	J:330451
Molecular Function	GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity	IDA	J:154329
Molecular Function	GO:0004473	malate dehydrogenase (decarboxylating) (NADP+) activity	IBA	J:265628
Molecular Function	GO:0004470	malic enzyme activity	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0051287	NAD binding	IEA	J:72247
Molecular Function	GO:0008948	oxaloacetate decarboxylase activity	IEA	J:72245
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0005759	mitochondrial matrix	IDA	J:330451
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Biological Process	GO:0006108	malate metabolic process	IBA	J:265628
Biological Process	GO:0008152	metabolic process	IEA	J:60000
Biological Process	GO:0006090	pyruvate metabolic process	IBA	J:265628
Biological Process	GO:0006090	pyruvate metabolic process	IDA	J:154329
Biological Process	GO:1902031	regulation of NADP metabolic process	ISO	J:164563