GO Annotations Graph

• Symbol: Slc6a8
• Name: solute carrier family 6 (neurotransmitter transporter, creatine), member 8
• ID: MGI:2147834

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0015220	choline transmembrane transporter activity	ISO	J:155856
Molecular Function	GO:0005308	creatine transmembrane transporter activity	ISO	J:155856
Molecular Function	GO:0005308	creatine transmembrane transporter activity	ISS	J:19724
Molecular Function	GO:0005309	creatine:sodium symporter activity	ISO	J:155856
Molecular Function	GO:0005309	creatine:sodium symporter activity	IDA	J:83328
Molecular Function	GO:0005309	creatine:sodium symporter activity	ISO	J:164563
Molecular Function	GO:0015293	symporter activity	IEA	J:60000
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0045202	synapse	ISO	J:155856
Biological Process	GO:0015881	creatine transmembrane transport	ISO	J:164563
Biological Process	GO:0015881	creatine transmembrane transport	ISO	J:155856
Biological Process	GO:0015881	creatine transmembrane transport	ISS	J:19724
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0006836	neurotransmitter transport	IEA	J:72247
Biological Process	GO:0071705	nitrogen compound transport	ISO	J:164563
Biological Process	GO:0030163	protein catabolic process	ISO	J:155856
Biological Process	GO:0035725	sodium ion transmembrane transport	IBA	J:265628
Biological Process	GO:0006814	sodium ion transport	IEA	J:60000