GO Annotations Graph

• Symbol: Ehmt2
• Name: euchromatic histone lysine N-methyltransferase 2
• ID: MGI:2148922

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0070742	C2H2 zinc finger domain binding	ISO	J:164563
Molecular Function	GO:0070742	C2H2 zinc finger domain binding	IPI	J:114884
Molecular Function	GO:0046976	histone H3K27 methyltransferase activity	IDA	J:97244
Molecular Function	GO:0046976	histone H3K27 methyltransferase activity	IMP	J:123364
Molecular Function	GO:0140759	histone H3K56 methyltransferase activity	ISO	J:164563
Molecular Function	GO:0140759	histone H3K56 methyltransferase activity	IMP	J:184478
Molecular Function	GO:0046974	histone H3K9 methyltransferase activity	EXP	J:231284
Molecular Function	GO:0046974	histone H3K9 methyltransferase activity	IMP	J:143343
Molecular Function	GO:0046974	histone H3K9 methyltransferase activity	IDA	J:97244
Molecular Function	GO:0046974	histone H3K9 methyltransferase activity	IBA	J:265628
Molecular Function	GO:0046974	histone H3K9 methyltransferase activity	IMP	J:123364
Molecular Function	GO:0046974	histone H3K9 methyltransferase activity	IMP	J:100751
Molecular Function	GO:0046974	histone H3K9 methyltransferase activity	IMP	J:123269
Molecular Function	GO:0046974	histone H3K9 methyltransferase activity	IDA	J:148615
Molecular Function	GO:0140948	histone H3K9 monomethyltransferase activity	IEA	J:72245
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0008168	methyltransferase activity	IEA	J:60000
Molecular Function	GO:0002039	p53 binding	ISO	J:164563
Molecular Function	GO:1990841	promoter-specific chromatin binding	ISO	J:73065
Molecular Function	GO:1990841	promoter-specific chromatin binding	ISO	J:73065
Molecular Function	GO:1990841	promoter-specific chromatin binding	ISO	J:73065
Molecular Function	GO:1990841	promoter-specific chromatin binding	IDA	J:227373
Molecular Function	GO:0005515	protein binding	IPI	J:114884
Molecular Function	GO:0005515	protein binding	IPI	J:97244
Molecular Function	GO:0005515	protein binding	IPI	J:277855
Molecular Function	GO:0005515	protein binding	IPI	J:159133
Molecular Function	GO:0005515	protein binding	IPI	J:153740
Molecular Function	GO:0005515	protein binding	IPI	J:213416
Molecular Function	GO:0005515	protein binding	IPI	J:245277
Molecular Function	GO:0005515	protein binding	IPI	J:306882
Molecular Function	GO:0005515	protein binding	IPI	J:109524
Molecular Function	GO:0005515	protein binding	IPI	J:209140
Molecular Function	GO:0005515	protein binding	IPI	J:143343
Molecular Function	GO:0016279	protein-lysine N-methyltransferase activity	ISO	J:164563
Molecular Function	GO:0016279	protein-lysine N-methyltransferase activity	IDA	J:148615
Molecular Function	GO:0016279	protein-lysine N-methyltransferase activity	ISO	J:148615
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	J:173973
Molecular Function	GO:0001222	transcription corepressor binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0000785	chromatin	IBA	J:265628
Cellular Component	GO:0000785	chromatin	ISO	J:148615
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0016607	nuclear speck	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-573373
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-573385
Cellular Component	GO:0005634	nucleus	IDA	J:114884
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:277855
Cellular Component	GO:0005634	nucleus	IDA	J:97244
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:227373
Cellular Component	GO:0005634	nucleus	ISO	J:148615
Cellular Component	GO:0005634	nucleus	IDA	J:94206
Biological Process	GO:0048148	behavioral response to cocaine	IMP	J:212015
Biological Process	GO:0071314	cellular response to cocaine	IDA	J:212015
Biological Process	GO:0009267	cellular response to starvation	ISO	J:73065
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	ISO	J:155856
Biological Process	GO:0006325	chromatin organization	IEA	J:60000
Biological Process	GO:0006306	DNA methylation	IDA	J:143343
Biological Process	GO:0006306	DNA methylation	IBA	J:265628
Biological Process	GO:0010424	DNA methylation on cytosine within a CG sequence	IMP	J:123364
Biological Process	GO:0009566	fertilization	IMP	J:123269
Biological Process	GO:0034968	histone lysine methylation	IEA	J:72247
Biological Process	GO:0007616	long-term memory	ISO	J:155856
Biological Process	GO:0032259	methylation	IEA	J:60000
Biological Process	GO:1902902	negative regulation of autophagosome assembly	IMP	J:205012
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:212015
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:205012
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:205012
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:212015
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:121427
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:212015
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:205012
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:148615
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:212015
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:205012
Biological Process	GO:0048665	neuron fate specification	IMP	J:212015
Biological Process	GO:0048599	oocyte development	IMP	J:123269
Biological Process	GO:0048599	oocyte development	IMP	J:123269
Biological Process	GO:0035265	organ growth	IMP	J:123269
Biological Process	GO:0018027	peptidyl-lysine dimethylation	ISO	J:164563
Biological Process	GO:0018027	peptidyl-lysine dimethylation	IBA	J:265628
Biological Process	GO:0036166	phenotypic switching	IMP	J:212015
Biological Process	GO:0006479	protein methylation	IMP	J:123269
Biological Process	GO:0044030	regulation of DNA methylation	ISO	J:155856
Biological Process	GO:0006275	regulation of DNA replication	ISO	J:164563
Biological Process	GO:0006275	regulation of DNA replication	IMP	J:184478
Biological Process	GO:0051570	regulation of histone H3-K9 methylation	IBA	J:265628
Biological Process	GO:0031060	regulation of histone methylation	ISO	J:155856
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IMP	J:123269
Biological Process	GO:0007286	spermatid development	IMP	J:123269
Biological Process	GO:0007130	synaptonemal complex assembly	IMP	J:123269