GO Annotations Graph

• Symbol: Dock2
• Name: dedicator of cyto-kinesis 2
• ID: MGI:2149010

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005096	GTPase activator activity	IMP	J:84581
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ISO	J:164563
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IBA	J:265628
Molecular Function	GO:0031267	small GTPase binding	IBA	J:265628
Molecular Function	GO:0042608	T cell receptor binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Biological Process	GO:0030036	actin cytoskeleton organization	IEA	J:72247
Biological Process	GO:0046631	alpha-beta T cell activation	IMP	J:84581
Biological Process	GO:0046633	alpha-beta T cell proliferation	IMP	J:84581
Biological Process	GO:0016477	cell migration	IBA	J:265628
Biological Process	GO:0006935	chemotaxis	IMP	J:71005
Biological Process	GO:0007010	cytoskeleton organization	IDA	J:71005
Biological Process	GO:0001768	establishment of T cell polarity	IMP	J:84581
Biological Process	GO:0001771	immunological synapse formation	IMP	J:84581
Biological Process	GO:0044351	macropinocytosis	IMP	J:176441
Biological Process	GO:0001766	membrane raft polarization	IMP	J:84581
Biological Process	GO:0002277	myeloid dendritic cell activation involved in immune response	IMP	J:176441
Biological Process	GO:0007520	myoblast fusion	IBA	J:265628
Biological Process	GO:0045060	negative thymic T cell selection	IMP	J:84581
Biological Process	GO:0050766	positive regulation of phagocytosis	IMP	J:176441
Biological Process	GO:0035022	positive regulation of Rac protein signal transduction	IC	J:84581
Biological Process	GO:0045059	positive thymic T cell selection	IMP	J:84581
Biological Process	GO:0007264	small GTPase mediated signal transduction	IEA	J:72247
Biological Process	GO:0042110	T cell activation	IMP	J:84581
Biological Process	GO:0042098	T cell proliferation	IMP	J:84581