GO Annotations Graph

• Symbol: Spred1
• Name: sprouty protein with EVH-1 domain 1, related sequence
• ID: MGI:2150016

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019902	phosphatase binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:130605
Molecular Function	GO:0005515	protein binding	IPI	J:82566
Molecular Function	GO:0019901	protein kinase binding	IPI	J:183209
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	IBA	J:265628
Molecular Function	GO:0030291	protein serine/threonine kinase inhibitor activity	IDA	J:183209
Molecular Function	GO:0005173	stem cell factor receptor binding	IPI	J:82566
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Biological Process	GO:0007275	multicellular organism development	IEA	J:72247
Biological Process	GO:0016525	negative regulation of angiogenesis	IMP	J:230992
Biological Process	GO:0016525	negative regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis	IDA	J:139708
Biological Process	GO:0010719	negative regulation of epithelial to mesenchymal transition	IDA	J:287032
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	IDA	J:230992
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	IDA	J:287039
Biological Process	GO:1902747	negative regulation of lens fiber cell differentiation	IDA	J:287039
Biological Process	GO:0043409	negative regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0043409	negative regulation of MAPK cascade	IBA	J:265628
Biological Process	GO:0043409	negative regulation of MAPK cascade	IMP	J:82566
Biological Process	GO:0010801	negative regulation of peptidyl-threonine phosphorylation	ISO	J:164563
Biological Process	GO:0010801	negative regulation of peptidyl-threonine phosphorylation	IDA	J:183209
Biological Process	GO:0006469	negative regulation of protein kinase activity	ISO	J:164563
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	IDA	J:287032
Biological Process	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	IDA	J:183209
Biological Process	GO:0090311	regulation of protein deacetylation	IDA	J:183209
Biological Process	GO:0009966	regulation of signal transduction	IEA	J:72247
Biological Process	GO:0060979	vasculogenesis involved in coronary vascular morphogenesis	ISO	J:164563