GO Annotations Graph

• Symbol: Tmc1
• Name: transmembrane channel-like gene family 1
• ID: MGI:2151016

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008381	mechanosensitive monoatomic ion channel activity	IMP	J:232159
Molecular Function	GO:0008381	mechanosensitive monoatomic ion channel activity	IGI	J:232159
Molecular Function	GO:0008381	mechanosensitive monoatomic ion channel activity	IMP	J:232159
Molecular Function	GO:0005515	protein binding	IPI	J:249939
Molecular Function	GO:0005515	protein binding	IPI	J:257320
Molecular Function	GO:0005515	protein binding	IPI	J:214830
Molecular Function	GO:0005245	voltage-gated calcium channel activity	IBA	J:265628
Molecular Function	GO:0005245	voltage-gated calcium channel activity	IGI	J:201662
Molecular Function	GO:0005245	voltage-gated calcium channel activity	IMP	J:201662
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:132871
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IEA	J:72247
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9659536
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9663360
Cellular Component	GO:0032426	stereocilium tip	IDA	J:184419
Biological Process	GO:0060117	auditory receptor cell development	IMP	J:184419
Biological Process	GO:0070588	calcium ion transmembrane transport	IGI	J:201662
Biological Process	GO:0070588	calcium ion transmembrane transport	IMP	J:201662
Biological Process	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	IBA	J:265628
Biological Process	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	IGI	J:184419
Biological Process	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	IMP	J:184419
Biological Process	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	IMP	J:201662
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:1903169	regulation of calcium ion transmembrane transport	IMP	J:232159
Biological Process	GO:1903169	regulation of calcium ion transmembrane transport	IGI	J:232159
Biological Process	GO:1903169	regulation of calcium ion transmembrane transport	IMP	J:232159
Biological Process	GO:0007605	sensory perception of sound	IMP	MGI:MGI:48774
Biological Process	GO:0060005	vestibular reflex	IBA	J:265628
Biological Process	GO:0060005	vestibular reflex	IGI	J:184419
Biological Process	GO:0060005	vestibular reflex	IGI	J:232159
Biological Process	GO:0060005	vestibular reflex	IMP	J:232159
Biological Process	GO:0060005	vestibular reflex	IMP	J:232159