GO Annotations Graph

• Symbol: Tirap
• Name: toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
• ID: MGI:2152213

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IPI	J:71392
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0140677	molecular function activator activity	ISO	J:164563
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	IDA	J:171185
Molecular Function	GO:0005515	protein binding	IPI	J:180126
Molecular Function	GO:0005515	protein binding	IPI	J:169794
Molecular Function	GO:0005515	protein binding	IPI	J:71392
Molecular Function	GO:0005080	protein kinase C binding	ISO	J:164563
Molecular Function	GO:0035663	Toll-like receptor 2 binding	IPI	J:169893
Molecular Function	GO:0035663	Toll-like receptor 2 binding	ISO	J:164563
Molecular Function	GO:0035662	Toll-like receptor 4 binding	ISO	J:164563
Molecular Function	GO:0035662	Toll-like receptor 4 binding	IBA	J:265628
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0030139	endocytic vesicle	IDA	J:171185
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0032587	ruffle membrane	IDA	J:171185
Biological Process	GO:0070935	3'-UTR-mediated mRNA stabilization	ISO	J:164563
Biological Process	GO:0007250	activation of NF-kappaB-inducing kinase activity	ISO	J:164563
Biological Process	GO:0007166	cell surface receptor signaling pathway	ISO	J:71392
Biological Process	GO:0007166	cell surface receptor signaling pathway	IPI	J:72250
Biological Process	GO:0071221	cellular response to bacterial lipopeptide	IMP	J:96018
Biological Process	GO:0071223	cellular response to lipoteichoic acid	IMP	J:96018
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IMP	J:96018
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IBA	J:265628
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IMP	J:72250
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	ISO	J:71392
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:96018
Biological Process	GO:0030099	myeloid cell differentiation	IMP	J:72250
Biological Process	GO:0030890	positive regulation of B cell proliferation	IMP	J:96773
Biological Process	GO:2000340	positive regulation of chemokine (C-X-C motif) ligand 1 production	IMP	J:122157
Biological Process	GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	IMP	J:122157
Biological Process	GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	IBA	J:265628
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IBA	J:265628
Biological Process	GO:0045089	positive regulation of innate immune response	IMP	J:122157
Biological Process	GO:0045089	positive regulation of innate immune response	IBA	J:265628
Biological Process	GO:0032735	positive regulation of interleukin-12 production	IMP	J:96773
Biological Process	GO:0032738	positive regulation of interleukin-15 production	ISO	J:164563
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:169893
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:122157
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IDA	J:169799
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:96773
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0032757	positive regulation of interleukin-8 production	IMP	J:122157
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:0046330	positive regulation of JNK cascade	ISO	J:164563
Biological Process	GO:0043507	positive regulation of JUN kinase activity	ISO	J:71392
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:96018
Biological Process	GO:0090023	positive regulation of neutrophil chemotaxis	IMP	J:169888
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IMP	J:96773
Biological Process	GO:0031334	positive regulation of protein-containing complex assembly	ISO	J:164563
Biological Process	GO:0034137	positive regulation of toll-like receptor 2 signaling pathway	ISO	J:164563
Biological Process	GO:0034141	positive regulation of toll-like receptor 3 signaling pathway	IDA	J:169893
Biological Process	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway	ISO	J:164563
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:164563
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:122157
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:96773
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:96018
Biological Process	GO:0045088	regulation of innate immune response	NAS	J:96773
Biological Process	GO:0032648	regulation of interferon-beta production	IDA	J:169792
Biological Process	GO:0032658	regulation of interleukin-15 production	IMP	J:169880
Biological Process	GO:0032872	regulation of stress-activated MAPK cascade	IBA	J:265628
Biological Process	GO:0009617	response to bacterium	ISO	J:71392
Biological Process	GO:0032496	response to lipopolysaccharide	ISO	J:164563
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0035665	TIRAP-dependent toll-like receptor 4 signaling pathway	ISO	J:164563
Biological Process	GO:0034142	toll-like receptor 4 signaling pathway	ISO	J:164563
Biological Process	GO:0032640	tumor necrosis factor production	IMP	J:96018