GO Annotations Graph

• Symbol: Ripk3
• Name: receptor-interacting serine-threonine kinase 3
• ID: MGI:2154952

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0004704	NF-kappaB-inducing kinase activity	IDA	J:57772
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:228302
Molecular Function	GO:0005515	protein binding	IPI	J:193287
Molecular Function	GO:0005515	protein binding	IPI	J:251915
Molecular Function	GO:0005515	protein binding	IPI	J:263339
Molecular Function	GO:0005515	protein binding	IPI	J:182381
Molecular Function	GO:0005515	protein binding	IPI	J:289444
Molecular Function	GO:0005515	protein binding	IPI	J:187699
Molecular Function	GO:0005515	protein binding	IPI	J:235313
Molecular Function	GO:0005515	protein binding	IPI	J:170814
Molecular Function	GO:0005515	protein binding	IPI	J:289088
Molecular Function	GO:0005515	protein binding	IPI	J:152731
Molecular Function	GO:0005515	protein binding	IPI	J:204592
Molecular Function	GO:0005515	protein binding	IPI	J:209137
Molecular Function	GO:0005515	protein binding	IPI	J:279494
Molecular Function	GO:0005515	protein binding	IPI	J:201938
Molecular Function	GO:0005515	protein binding	IPI	J:289066
Molecular Function	GO:0005515	protein binding	IPI	J:204620
Molecular Function	GO:0005515	protein binding	IPI	J:194185
Molecular Function	GO:0005515	protein binding	IPI	J:200967
Molecular Function	GO:0005515	protein binding	IPI	J:200967
Molecular Function	GO:0005515	protein binding	IPI	J:200967
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	IBA	J:265628
Molecular Function	GO:0004672	protein kinase activity	IDA	J:57772
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:289452
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:204620
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:289082
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:204592
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IDA	J:289444
Cellular Component	GO:0005737	cytoplasm	IDA	J:289082
Cellular Component	GO:0005737	cytoplasm	IDA	J:289452
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005622	intracellular anatomical structure	IDA	J:57772
Cellular Component	GO:0005634	nucleus	IDA	J:289452
Cellular Component	GO:0005634	nucleus	IDA	J:289082
Cellular Component	GO:0005634	nucleus	IDA	J:289444
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Biological Process	GO:0032147	activation of protein kinase activity	ISO	J:164563
Biological Process	GO:1990000	amyloid fibril formation	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0070301	cellular response to hydrogen peroxide	IMP	J:259866
Biological Process	GO:0051607	defense response to virus	IDA	J:289066
Biological Process	GO:0051607	defense response to virus	IMP	J:289096
Biological Process	GO:0051607	defense response to virus	IDA	J:289452
Biological Process	GO:0051607	defense response to virus	IDA	J:279203
Biological Process	GO:0051607	defense response to virus	IMP	J:290369
Biological Process	GO:0051607	defense response to virus	IMP	J:289088
Biological Process	GO:0051607	defense response to virus	IDA	J:289082
Biological Process	GO:0097528	execution phase of necroptosis	IMP	J:289096
Biological Process	GO:0097528	execution phase of necroptosis	IMP	J:290369
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IDA	J:57772
Biological Process	GO:0048535	lymph node development	IGI	J:176448
Biological Process	GO:0070266	necroptotic process	IMP	J:204620
Biological Process	GO:0070266	necroptotic process	ISO	J:164563
Biological Process	GO:0070266	necroptotic process	IGI	J:196028
Biological Process	GO:0070266	necroptotic process	IGI	J:170814
Biological Process	GO:0070266	necroptotic process	IGI	J:170814
Biological Process	GO:0070266	necroptotic process	IGI	J:170814
Biological Process	GO:0070266	necroptotic process	IGI	J:200967
Biological Process	GO:0070266	necroptotic process	IGI	J:177328
Biological Process	GO:0070266	necroptotic process	IGI	J:180684
Biological Process	GO:0070266	necroptotic process	IGI	J:180684
Biological Process	GO:0070266	necroptotic process	IGI	J:196028
Biological Process	GO:0097527	necroptotic signaling pathway	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	IDA	J:57772
Biological Process	GO:0051351	positive regulation of ligase activity	IDA	J:200967
Biological Process	GO:0060545	positive regulation of necroptotic process	IMP	J:214394
Biological Process	GO:0060545	positive regulation of necroptotic process	IDA	J:289066
Biological Process	GO:0060545	positive regulation of necroptotic process	IMP	J:182381
Biological Process	GO:0060545	positive regulation of necroptotic process	IMP	J:289088
Biological Process	GO:0060545	positive regulation of necroptotic process	ISO	J:164563
Biological Process	GO:0060545	positive regulation of necroptotic process	IDA	J:289082
Biological Process	GO:0060545	positive regulation of necroptotic process	IDA	J:289452
Biological Process	GO:0060545	positive regulation of necroptotic process	IMP	J:201937
Biological Process	GO:0060545	positive regulation of necroptotic process	IMP	J:214393
Biological Process	GO:0010940	positive regulation of necrotic cell death	IMP	J:235313
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0051353	positive regulation of oxidoreductase activity	IDA	J:200967
Biological Process	GO:0010922	positive regulation of phosphatase activity	ISO	J:164563
Biological Process	GO:0090312	positive regulation of protein deacetylation	IGI	J:194185
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	IMP	J:182381
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	IMP	J:200967
Biological Process	GO:0051347	positive regulation of transferase activity	IGI	J:200967
Biological Process	GO:0012501	programmed cell death	IEA	J:60000
Biological Process	GO:0097300	programmed necrotic cell death	IMP	J:259866
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0006476	protein deacetylation	IGI	J:194185
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0072593	reactive oxygen species metabolic process	IMP	J:200967
Biological Process	GO:0046006	regulation of activated T cell proliferation	IGI	J:176448
Biological Process	GO:0070235	regulation of activation-induced cell death of T cells	IGI	J:176448
Biological Process	GO:0002819	regulation of adaptive immune response	IGI	J:176448
Biological Process	GO:0042981	regulation of apoptotic process	IMP	J:289096
Biological Process	GO:0042981	regulation of apoptotic process	IMP	J:289088
Biological Process	GO:0042981	regulation of apoptotic process	IMP	J:290369
Biological Process	GO:0042981	regulation of apoptotic process	IDA	J:289082
Biological Process	GO:2000452	regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation	IGI	J:176448
Biological Process	GO:2000377	regulation of reactive oxygen species metabolic process	IMP	J:182381
Biological Process	GO:0001914	regulation of T cell mediated cytotoxicity	IGI	J:176448
Biological Process	GO:0032649	regulation of type II interferon production	IGI	J:176448
Biological Process	GO:0007165	signal transduction	IBA	J:265628
Biological Process	GO:0048536	spleen development	IGI	J:176448
Biological Process	GO:0033077	T cell differentiation in thymus	IGI	J:176448
Biological Process	GO:0043029	T cell homeostasis	IGI	J:176448
Biological Process	GO:0048538	thymus development	IGI	J:176448