GO Annotations Graph

• Symbol: Sesn1
• Name: sestrin 1
• ID: MGI:2155278

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0070728	leucine binding	ISO	J:164563
Molecular Function	GO:0070728	leucine binding	IBA	J:265628
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:214946
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0001650	fibrillar center	ISO	J:164563
Cellular Component	GO:0061700	GATOR2 complex	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Biological Process	GO:0098869	cellular oxidant detoxification	ISO	J:164563
Biological Process	GO:0034198	cellular response to amino acid starvation	ISO	J:164563
Biological Process	GO:0071230	cellular response to amino acid stimulus	IMP	J:214946
Biological Process	GO:0042149	cellular response to glucose starvation	ISO	J:164563
Biological Process	GO:0071233	cellular response to leucine	IBA	J:265628
Biological Process	GO:1990253	cellular response to leucine starvation	IBA	J:265628
Biological Process	GO:0030308	negative regulation of cell growth	IDA	J:233574
Biological Process	GO:1904262	negative regulation of TORC1 signaling	IMP	J:214946
Biological Process	GO:1904262	negative regulation of TORC1 signaling	ISO	J:164563
Biological Process	GO:1904262	negative regulation of TORC1 signaling	IBA	J:265628
Biological Process	GO:0016239	positive regulation of macroautophagy	IBA	J:265628
Biological Process	GO:0072593	reactive oxygen species metabolic process	ISO	J:164563
Biological Process	GO:0051896	regulation of protein kinase B signaling	IDA	J:189021
Biological Process	GO:1901031	regulation of response to reactive oxygen species	IEA	J:72247