GO Annotations Graph

• Symbol: Pkhd1
• Name: polycystic kidney and hepatic disease 1
• ID: MGI:2155808

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005515	protein binding	IPI	J:102836
Molecular Function	GO:0005515	protein binding	IPI	J:143394
Molecular Function	GO:0005515	protein binding	IPI	J:246963
Molecular Function	GO:0005515	protein binding	IPI	J:215153
Cellular Component	GO:0097731	9+0 non-motile cilium	IDA	J:215153
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:131370
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0000775	chromosome, centromeric region	IEA	J:60000
Cellular Component	GO:0036064	ciliary basal body	ISO	J:164563
Cellular Component	GO:0005929	cilium	IDA	J:296131
Cellular Component	GO:0005929	cilium	IDA	J:131370
Cellular Component	GO:0005929	cilium	IDA	J:187735
Cellular Component	GO:0005929	cilium	ISO	J:155856
Cellular Component	GO:0005929	cilium	ISO	J:164563
Cellular Component	GO:0005929	cilium	IDA	J:296158
Cellular Component	GO:0005929	cilium	IDA	J:246963
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:296109
Cellular Component	GO:0070062	extracellular exosome	IDA	J:187735
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005794	Golgi apparatus	IDA	J:296109
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0072686	mitotic spindle	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Biological Process	GO:0048754	branching morphogenesis of an epithelial tube	IMP	J:167782
Biological Process	GO:0045216	cell-cell junction organization	IMP	J:167782
Biological Process	GO:0060271	cilium assembly	IMP	J:143394
Biological Process	GO:0000132	establishment of mitotic spindle orientation	IMP	J:185863
Biological Process	GO:0006874	intracellular calcium ion homeostasis	ISO	J:164563
Biological Process	GO:0001822	kidney development	IDA	J:89193
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:1904036	negative regulation of epithelial cell apoptotic process	IMP	J:167782
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	IMP	J:167782
Biological Process	GO:0010824	regulation of centrosome duplication	ISO	J:164563
Biological Process	GO:1904054	regulation of cholangiocyte proliferation	ISO	J:164563
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0090175	regulation of establishment of planar polarity	IMP	J:185863
Biological Process	GO:0032006	regulation of TOR signaling	ISO	J:164563