Tlr3 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Tlr3
toll-like receptor 3
MGI:2156367

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003725	double-stranded RNA binding	ISO	J:164563
Molecular Function	GO:0003725	double-stranded RNA binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0038187	pattern recognition receptor activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:304592
Molecular Function	GO:0005515	protein binding	IPI	J:224712
Molecular Function	GO:0005515	protein binding	IPI	J:161113
Molecular Function	GO:0003723	RNA binding	IEA	J:60000
Molecular Function	GO:0038023	signaling receptor activity	IBA	J:265628
Molecular Function	GO:0004888	transmembrane signaling receptor activity	IEA	J:72247
Molecular Function	GO:0004888	transmembrane signaling receptor activity	IDA	J:242717
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IDA	J:242717
Biological Process	GO:0071360	cellular response to exogenous dsRNA	ISO	J:155856
Biological Process	GO:0098586	cellular response to virus	IMP	J:141299
Biological Process	GO:0032602	chemokine production	IMP	J:84679
Biological Process	GO:0032602	chemokine production	IMP	J:84679
Biological Process	GO:0032602	chemokine production	IMP	J:84679
Biological Process	GO:0032602	chemokine production	IMP	J:84679
Biological Process	GO:0006952	defense response	IMP	J:72167
Biological Process	GO:0051607	defense response to virus	TAS	J:161025
Biological Process	GO:0051607	defense response to virus	IGI	J:131989
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IGI	J:102721
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IMP	J:84679
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IDA	J:102721
Biological Process	GO:0007252	I-kappaB phosphorylation	ISO	J:164563
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0090594	inflammatory response to wounding	IDA	J:242717
Biological Process	GO:0045087	innate immune response	TAS	J:161025
Biological Process	GO:0032635	interleukin-6 production	IDA	J:132126
Biological Process	GO:0007254	JNK cascade	IMP	J:141299
Biological Process	GO:0007254	JNK cascade	IDA	J:102721
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:84679
Biological Process	GO:0010934	macrophage cytokine production	IDA	J:132126
Biological Process	GO:0000165	MAPK cascade	IMP	J:141299
Biological Process	GO:0001774	microglial cell activation	ISO	J:155856
Biological Process	GO:0002756	MyD88-independent toll-like receptor signaling pathway	IEA	J:72247
Biological Process	GO:0097527	necroptotic signaling pathway	ISO	J:164563
Biological Process	GO:0045766	positive regulation of angiogenesis	IGI	J:230992
Biological Process	GO:0032722	positive regulation of chemokine production	ISO	J:164563
Biological Process	GO:0032722	positive regulation of chemokine production	IMP	J:84679
Biological Process	GO:0001819	positive regulation of cytokine production	IEA	J:72247
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	IDA	J:242717
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IMP	J:84679
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IGI	J:102721
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IDA	J:102721
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IDA	J:152781
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IDA	J:152781
Biological Process	GO:0050729	positive regulation of inflammatory response	IEA	J:72247
Biological Process	GO:0032727	positive regulation of interferon-alpha production	ISO	J:164563
Biological Process	GO:0032728	positive regulation of interferon-beta production	IDA	J:161025
Biological Process	GO:0032728	positive regulation of interferon-beta production	ISS	J:113978
Biological Process	GO:0032728	positive regulation of interferon-beta production	ISO	J:164563
Biological Process	GO:0032735	positive regulation of interleukin-12 production	IDA	J:161025
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IDA	J:161025
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IDA	J:132126
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:117613
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:0046330	positive regulation of JNK cascade	IDA	J:102721
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IDA	J:132126
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:84679
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IMP	J:84679
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0034123	positive regulation of toll-like receptor signaling pathway	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:161025
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:141299
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IDA	J:161025
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:117613
Biological Process	GO:0032481	positive regulation of type I interferon production	IDA	J:131898
Biological Process	GO:0032729	positive regulation of type II interferon production	ISO	J:164563
Biological Process	GO:0034346	positive regulation of type III interferon production	IDA	J:131898
Biological Process	GO:0002730	regulation of dendritic cell cytokine production	IDA	J:143745
Biological Process	GO:0043331	response to dsRNA	ISO	J:155856
Biological Process	GO:0043330	response to exogenous dsRNA	IMP	J:84679
Biological Process	GO:0043330	response to exogenous dsRNA	ISO	J:170947
Biological Process	GO:0009615	response to virus	IMP	J:88906
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0034138	toll-like receptor 3 signaling pathway	IEA	J:72247
Biological Process	GO:0002224	toll-like receptor signaling pathway	ISO	J:164563
Biological Process	GO:0002224	toll-like receptor signaling pathway	ISO	J:155856
Biological Process	GO:0002224	toll-like receptor signaling pathway	IBA	J:265628
Biological Process	GO:0032606	type I interferon production	IDA	J:131898
Biological Process	GO:0032606	type I interferon production	IDA	J:131898
Biological Process	GO:0034343	type III interferon production	IDA	J:131898
Biological Process	GO:0034343	type III interferon production	IDA	J:131898

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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