GO Annotations Graph

• Symbol: Mlc1
• Name: megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)
• ID: MGI:2157910

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:171633
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:94404
Cellular Component	GO:0097450	astrocyte end-foot	IDA	J:94404
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:164563
Cellular Component	GO:0005901	caveola	ISO	J:155856
Cellular Component	GO:0005911	cell-cell junction	IDA	J:94404
Cellular Component	GO:0005911	cell-cell junction	ISO	J:73065
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:155856
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005769	early endosome	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:94404
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	IBA	J:265628
Cellular Component	GO:0005768	endosome	ISO	J:164563
Cellular Component	GO:0005764	lysosome	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:94404
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0055037	recycling endosome	ISO	J:155856
Biological Process	GO:0072584	caveolin-mediated endocytosis	ISO	J:155856
Biological Process	GO:0071397	cellular response to cholesterol	ISO	J:155856
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0032388	positive regulation of intracellular transport	ISO	J:164563
Biological Process	GO:0015031	protein transport	ISO	J:155856
Biological Process	GO:0047484	regulation of response to osmotic stress	ISO	J:164563
Biological Process	GO:0047484	regulation of response to osmotic stress	IBA	J:265628
Biological Process	GO:0016192	vesicle-mediated transport	ISO	J:155856