GO Annotations Graph

• Symbol: Mlph
• Name: melanophilin
• ID: MGI:2176380

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	IBA	J:265628
Molecular Function	GO:0003779	actin binding	IDA	J:80040
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0051010	microtubule plus-end binding	IDA	J:104400
Molecular Function	GO:0051010	microtubule plus-end binding	IDA	J:104400
Molecular Function	GO:0051010	microtubule plus-end binding	IPI	J:100998
Molecular Function	GO:0060090	molecular adaptor activity	EXP	J:240278
Molecular Function	GO:0060090	molecular adaptor activity	IDA	J:240278
Molecular Function	GO:0017022	myosin binding	ISO	J:164563
Molecular Function	GO:0017022	myosin binding	IBA	J:265628
Molecular Function	GO:0017022	myosin binding	IDA	J:83919
Molecular Function	GO:0031489	myosin V binding	IPI	J:240278
Molecular Function	GO:0031489	myosin V binding	IPI	J:87907
Molecular Function	GO:0031489	myosin V binding	IPI	J:75876
Molecular Function	GO:0005515	protein binding	IPI	J:155184
Molecular Function	GO:0005515	protein binding	IPI	J:155184
Molecular Function	GO:0005515	protein binding	IPI	J:75312
Molecular Function	GO:0005515	protein binding	IPI	J:104400
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	ISO	J:164563
Molecular Function	GO:0031267	small GTPase binding	ISO	J:164563
Molecular Function	GO:0031267	small GTPase binding	IDA	J:83919
Cellular Component	GO:0015629	actin cytoskeleton	IDA	J:80040
Cellular Component	GO:0030864	cortical actin cytoskeleton	IBA	J:265628
Cellular Component	GO:0030864	cortical actin cytoskeleton	IDA	J:104400
Cellular Component	GO:0030864	cortical actin cytoskeleton	IDA	J:104400
Cellular Component	GO:0030425	dendrite	ISO	J:164563
Cellular Component	GO:0042470	melanosome	IDA	J:100998
Cellular Component	GO:0042470	melanosome	IDA	J:104400
Cellular Component	GO:0042470	melanosome	IDA	J:75876
Cellular Component	GO:0042470	melanosome	IDA	J:87907
Cellular Component	GO:0042470	melanosome	TAS	J:80040
Cellular Component	GO:0042470	melanosome	TAS	J:83919
Cellular Component	GO:0005815	microtubule organizing center	IDA	J:104400
Cellular Component	GO:0005815	microtubule organizing center	IDA	J:104400
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0001725	stress fiber	IDA	J:104400
Cellular Component	GO:0001725	stress fiber	IDA	J:104400
Cellular Component	GO:0016461	unconventional myosin complex	IMP	J:240278
Biological Process	GO:0006886	intracellular protein transport	IEA	J:72247
Biological Process	GO:0030318	melanocyte differentiation	IMP	J:71302
Biological Process	GO:0030318	melanocyte differentiation	IMP	J:29467
Biological Process	GO:0032400	melanosome localization	IMP	J:87907
Biological Process	GO:0032400	melanosome localization	IMP	J:105323
Biological Process	GO:0032400	melanosome localization	IMP	J:75876
Biological Process	GO:0043473	pigmentation	IMP	J:29467
Biological Process	GO:0043473	pigmentation	IMP	J:12970
Biological Process	GO:0006605	protein targeting	IMP	J:75876
Biological Process	GO:0006605	protein targeting	IMP	J:105323