GO Annotations Graph

• Symbol: Dicer1
• Name: dicer 1, ribonuclease type III
• ID: MGI:2177178

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0004530	deoxyribonuclease I activity	IBA	J:265628
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0003725	double-stranded RNA binding	ISO	J:164563
Molecular Function	GO:0004519	endonuclease activity	IEA	J:60000
Molecular Function	GO:0004386	helicase activity	IEA	J:60000
Molecular Function	GO:0016787	hydrolase activity	IEA	J:72247
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0035198	miRNA binding	IDA	J:152654
Molecular Function	GO:0004518	nuclease activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0070883	pre-miRNA binding	ISO	J:164563
Molecular Function	GO:0070883	pre-miRNA binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:112901
Molecular Function	GO:0005515	protein binding	IPI	J:148059
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:164563
Molecular Function	GO:0004525	ribonuclease III activity	ISO	J:164563
Molecular Function	GO:0004525	ribonuclease III activity	TAS	Reactome:R-MMU-9709033
Molecular Function	GO:0004525	ribonuclease III activity	IBA	J:265628
Molecular Function	GO:0003723	RNA binding	IBA	J:265628
Molecular Function	GO:0004521	RNA endonuclease activity	ISO	J:164563
Molecular Function	GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	IEA	J:72247
Molecular Function	GO:0035197	siRNA binding	ISO	J:164563
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:203415
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9709033
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	ISO	J:155856
Cellular Component	GO:0070062	extracellular exosome	ISO	J:164563
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:100708
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:100708
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:100708
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:100708
Cellular Component	GO:0030426	growth cone	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0099092	postsynaptic density, intracellular component	IDA	J:100708
Cellular Component	GO:0099092	postsynaptic density, intracellular component	IDA	J:100708
Cellular Component	GO:0099092	postsynaptic density, intracellular component	IDA	J:100708
Cellular Component	GO:0099092	postsynaptic density, intracellular component	IDA	J:100708
Cellular Component	GO:0016442	RISC complex	IBA	J:265628
Cellular Component	GO:0016442	RISC complex	IDA	J:188024
Cellular Component	GO:0070578	RISC-loading complex	ISO	J:164563
Biological Process	GO:0048856	anatomical structure development	IMP	J:188151
Biological Process	GO:0001525	angiogenesis	IMP	J:123635
Biological Process	GO:0001525	angiogenesis	IMP	J:97770
Biological Process	GO:0006309	apoptotic DNA fragmentation	IBA	J:265628
Biological Process	GO:0048754	branching morphogenesis of an epithelial tube	IMP	J:106072
Biological Process	GO:0055013	cardiac muscle cell development	IMP	J:131962
Biological Process	GO:0055013	cardiac muscle cell development	IMP	J:131962
Biological Process	GO:0061309	cardiac neural crest cell development involved in outflow tract morphogenesis	IMP	J:166758
Biological Process	GO:0051216	cartilage development	IMP	J:166758
Biological Process	GO:0008283	cell population proliferation	IMP	J:163670
Biological Process	GO:0021987	cerebral cortex development	IMP	J:143171
Biological Process	GO:0051607	defense response to virus	IMP	J:123635
Biological Process	GO:0048565	digestive tract development	IMP	J:170489
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	IMP	J:103424
Biological Process	GO:0030326	embryonic limb morphogenesis	IMP	J:100475
Biological Process	GO:0048730	epidermis morphogenesis	IMP	J:110268
Biological Process	GO:0061548	ganglion development	IMP	J:166758
Biological Process	GO:0010467	gene expression	IMP	J:110268
Biological Process	GO:0010467	gene expression	IMP	J:110268
Biological Process	GO:0098795	global gene silencing by mRNA cleavage	ISO	J:164563
Biological Process	GO:0071335	hair follicle cell proliferation	IMP	J:110268
Biological Process	GO:0001942	hair follicle development	IMP	J:110268
Biological Process	GO:0031069	hair follicle morphogenesis	IMP	J:110268
Biological Process	GO:0060119	inner ear receptor cell development	IMP	J:148395
Biological Process	GO:0060576	intestinal epithelial cell development	IGI	J:170489
Biological Process	GO:0030324	lung development	IMP	J:106072
Biological Process	GO:0000212	meiotic spindle organization	IMP	J:203415
Biological Process	GO:0035196	miRNA processing	IMP	J:164021
Biological Process	GO:0035196	miRNA processing	IMP	J:203415
Biological Process	GO:0035196	miRNA processing	ISO	J:164563
Biological Process	GO:0035196	miRNA processing	IMP	J:160526
Biological Process	GO:0035196	miRNA processing	IMP	J:100475
Biological Process	GO:0035196	miRNA processing	IMP	J:106792
Biological Process	GO:0035196	miRNA processing	IMP	J:96031
Biological Process	GO:0048255	mRNA stabilization	IMP	J:188151
Biological Process	GO:0035264	multicellular organism growth	IMP	J:110268
Biological Process	GO:0014835	myoblast differentiation involved in skeletal muscle regeneration	IMP	J:181629
Biological Process	GO:0035194	ncRNA-mediated post-transcriptional gene silencing	IMP	J:96031
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0060253	negative regulation of glial cell proliferation	IMP	J:164021
Biological Process	GO:0010626	negative regulation of Schwann cell proliferation	IMP	J:164021
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:164021
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:160526
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	ISO	J:164563
Biological Process	GO:0021675	nerve development	IMP	J:160526
Biological Process	GO:0048812	neuron projection morphogenesis	IMP	J:160526
Biological Process	GO:0038061	NIK/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0021889	olfactory bulb interneuron differentiation	IMP	J:133461
Biological Process	GO:0031508	pericentric heterochromatin formation	IMP	J:96031
Biological Process	GO:0032290	peripheral nervous system myelin formation	IMP	J:160526
Biological Process	GO:0032290	peripheral nervous system myelin formation	IMP	J:164021
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	ISO	J:155856
Biological Process	GO:0010595	positive regulation of endothelial cell migration	ISO	J:155856
Biological Process	GO:1904906	positive regulation of endothelial cell-matrix adhesion via fibronectin	ISO	J:155856
Biological Process	GO:1903142	positive regulation of establishment of endothelial barrier	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:197739
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:110268
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:110268
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:166758
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:110268
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:110268
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:110268
Biological Process	GO:1904899	positive regulation of hepatic stellate cell proliferation	ISO	J:155856
Biological Process	GO:2000630	positive regulation of miRNA metabolic process	IMP	J:167546
Biological Process	GO:0031643	positive regulation of myelination	IMP	J:160526
Biological Process	GO:0031643	positive regulation of myelination	IMP	J:164021
Biological Process	GO:0014040	positive regulation of Schwann cell differentiation	IMP	J:164021
Biological Process	GO:0014040	positive regulation of Schwann cell differentiation	IMP	J:160526
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:164021
Biological Process	GO:1905564	positive regulation of vascular endothelial cell proliferation	ISO	J:155856
Biological Process	GO:0009791	post-embryonic development	IMP	J:110268
Biological Process	GO:0009791	post-embryonic development	IMP	J:143171
Biological Process	GO:0031054	pre-miRNA processing	ISO	J:164563
Biological Process	GO:0031054	pre-miRNA processing	IBA	J:265628
Biological Process	GO:0031054	pre-miRNA processing	IDA	J:152654
Biological Process	GO:0051726	regulation of cell cycle	IMP	J:163670
Biological Process	GO:0070173	regulation of enamel mineralization	IMP	J:160269
Biological Process	GO:0030856	regulation of epithelial cell differentiation	IMP	J:160269
Biological Process	GO:0010468	regulation of gene expression	IMP	J:172651
Biological Process	GO:0010468	regulation of gene expression	IMP	J:176882
Biological Process	GO:0010468	regulation of gene expression	IMP	J:163670
Biological Process	GO:0010468	regulation of gene expression	IMP	J:172651
Biological Process	GO:0050727	regulation of inflammatory response	IMP	J:138683
Biological Process	GO:2000628	regulation of miRNA metabolic process	IMP	J:123635
Biological Process	GO:2000628	regulation of miRNA metabolic process	IMP	J:133461
Biological Process	GO:2000628	regulation of miRNA metabolic process	IMP	J:197739
Biological Process	GO:2000628	regulation of miRNA metabolic process	IMP	J:190038
Biological Process	GO:2000628	regulation of miRNA metabolic process	IMP	J:166758
Biological Process	GO:2000628	regulation of miRNA metabolic process	IMP	J:181629
Biological Process	GO:2000628	regulation of miRNA metabolic process	IMP	J:190038
Biological Process	GO:0010660	regulation of muscle cell apoptotic process	IMP	J:181629
Biological Process	GO:0031641	regulation of myelination	IMP	J:158669
Biological Process	GO:0050767	regulation of neurogenesis	IMP	J:133461
Biological Process	GO:0045664	regulation of neuron differentiation	IMP	J:143171
Biological Process	GO:0045664	regulation of neuron differentiation	IMP	J:125222
Biological Process	GO:0008593	regulation of Notch signaling pathway	IC	J:164021
Biological Process	GO:0042487	regulation of odontogenesis of dentin-containing tooth	IMP	J:160269
Biological Process	GO:0048713	regulation of oligodendrocyte differentiation	IMP	J:158669
Biological Process	GO:0001932	regulation of protein phosphorylation	IMP	J:164021
Biological Process	GO:0045589	regulation of regulatory T cell differentiation	IMP	J:138683
Biological Process	GO:0051252	regulation of RNA metabolic process	IMP	J:123635
Biological Process	GO:2000736	regulation of stem cell differentiation	IMP	J:96031
Biological Process	GO:0045069	regulation of viral genome replication	IMP	J:123635
Biological Process	GO:0048608	reproductive structure development	IMP	J:187838
Biological Process	GO:0070922	RISC complex assembly	ISO	J:164563
Biological Process	GO:0090501	RNA phosphodiester bond hydrolysis	IBA	J:265628
Biological Process	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	ISO	J:164563
Biological Process	GO:0006396	RNA processing	IMP	J:132315
Biological Process	GO:0006396	RNA processing	IDA	J:86391
Biological Process	GO:0031047	RNA-mediated gene silencing	IEA	J:60000
Biological Process	GO:0006364	rRNA processing	IEA	J:72247
Biological Process	GO:0030422	siRNA processing	IMP	J:203415
Biological Process	GO:0030422	siRNA processing	ISO	J:164563
Biological Process	GO:0030422	siRNA processing	IBA	J:265628
Biological Process	GO:0030422	siRNA processing	IDA	J:86391
Biological Process	GO:0007284	spermatogonial cell division	IMP	J:133129
Biological Process	GO:0021522	spinal cord motor neuron differentiation	IMP	J:174745
Biological Process	GO:0051225	spindle assembly	IMP	J:119483
Biological Process	GO:0048536	spleen development	IMP	J:170489
Biological Process	GO:0019827	stem cell population maintenance	IMP	J:86391
Biological Process	GO:0001834	trophectodermal cell proliferation	IMP	J:163670
Biological Process	GO:0010070	zygote asymmetric cell division	IMP	J:119483