GO Annotations Graph

• Symbol: Hps4
• Name: HPS4, biogenesis of lysosomal organelles complex 3 subunit 2
• ID: MGI:2177742

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ISO	J:164563
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IBA	J:265628
Molecular Function	GO:0046983	protein dimerization activity	ISO	J:164563
Molecular Function	GO:0046983	protein dimerization activity	ISS	J:113973
Molecular Function	GO:0042803	protein homodimerization activity	ISS	J:113973
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0031267	small GTPase binding	IPI	J:235260
Molecular Function	GO:0031267	small GTPase binding	ISO	J:164563
Molecular Function	GO:0031267	small GTPase binding	IPI	J:230050
Cellular Component	GO:0031085	BLOC-3 complex	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISS	J:113925
Cellular Component	GO:0031410	cytoplasmic vesicle	IDA	J:75144
Cellular Component	GO:0005765	lysosomal membrane	IBA	J:265628
Cellular Component	GO:0005764	lysosome	ISO	J:164563
Cellular Component	GO:0005764	lysosome	ISS	J:113973
Cellular Component	GO:0042470	melanosome	ISO	J:164563
Cellular Component	GO:0042470	melanosome	ISS	J:113973
Cellular Component	GO:0016020	membrane	ISS	J:113925
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0042827	platelet dense granule	ISO	J:164563
Biological Process	GO:0007596	blood coagulation	IMP	J:7327
Biological Process	GO:0046907	intracellular transport	NAS	J:320062
Biological Process	GO:0007040	lysosome organization	ISS	J:113973
Biological Process	GO:0007040	lysosome organization	ISO	J:164563
Biological Process	GO:0030318	melanocyte differentiation	IMP	J:75144
Biological Process	GO:1903232	melanosome assembly	ISO	J:164563
Biological Process	GO:1903232	melanosome assembly	NAS	J:320062
Biological Process	GO:1903232	melanosome assembly	IBA	J:265628
Biological Process	GO:0006996	organelle organization	IMP	J:75144
Biological Process	GO:0060155	platelet dense granule organization	NAS	J:235260
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0050821	protein stabilization	ISS	J:113973
Biological Process	GO:0006605	protein targeting	ISO	J:164563
Biological Process	GO:0006605	protein targeting	ISS	J:113973
Biological Process	GO:0006605	protein targeting	IBA	J:265628
Biological Process	GO:0016192	vesicle-mediated transport	IEA	J:72247