GO Annotations Graph

• Symbol: Prpf8
• Name: pre-mRNA processing factor 8
• ID: MGI:2179381

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	ISO	J:164563
Molecular Function	GO:0140492	metal-dependent deubiquitinase activity	IEA	J:72247
Molecular Function	GO:0097157	pre-mRNA intronic binding	IBA	J:265628
Molecular Function	GO:0003723	RNA binding	IEA	J:72247
Molecular Function	GO:0003723	RNA binding	IEA	J:60000
Molecular Function	GO:0030619	U1 snRNA binding	IBA	J:265628
Molecular Function	GO:0030620	U2 snRNA binding	IBA	J:265628
Molecular Function	GO:0030623	U5 snRNA binding	IBA	J:265628
Molecular Function	GO:0017070	U6 snRNA binding	IBA	J:265628
Cellular Component	GO:0071013	catalytic step 2 spliceosome	ISO	J:164563
Cellular Component	GO:0071013	catalytic step 2 spliceosome	IBA	J:265628
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0030532	small nuclear ribonucleoprotein complex	ISO	J:155856
Cellular Component	GO:0005681	spliceosomal complex	IEA	J:60000
Cellular Component	GO:0005681	spliceosomal complex	IEA	J:72247
Cellular Component	GO:0071006	U2-type catalytic step 1 spliceosome	ISO	J:164563
Cellular Component	GO:0071007	U2-type catalytic step 2 spliceosome	ISO	J:164563
Cellular Component	GO:0071005	U2-type precatalytic spliceosome	ISO	J:164563
Cellular Component	GO:0046540	U4/U6 x U5 tri-snRNP complex	ISO	J:164563
Cellular Component	GO:0005682	U5 snRNP	IBA	J:265628
Cellular Component	GO:0005682	U5 snRNP	ISO	J:73065
Biological Process	GO:0071222	cellular response to lipopolysaccharide	ISO	J:155856
Biological Process	GO:0071356	cellular response to tumor necrosis factor	ISO	J:155856
Biological Process	GO:0006397	mRNA processing	IEA	J:60000
Biological Process	GO:0000398	mRNA splicing, via spliceosome	ISO	J:164563
Biological Process	GO:0000398	mRNA splicing, via spliceosome	ISO	J:73065
Biological Process	GO:0008380	RNA splicing	IEA	J:60000
Biological Process	GO:0000244	spliceosomal tri-snRNP complex assembly	ISO	J:164563
Biological Process	GO:0000244	spliceosomal tri-snRNP complex assembly	IBA	J:265628