Nlgn1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Nlgn1
neuroligin 1
MGI:2179435

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0050839	cell adhesion molecule binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0042043	neurexin family protein binding	ISO	J:155856
Molecular Function	GO:0042043	neurexin family protein binding	IPI	J:175147
Molecular Function	GO:0042043	neurexin family protein binding	IMP	J:116404
Molecular Function	GO:0042043	neurexin family protein binding	IPI	J:84070
Molecular Function	GO:0042043	neurexin family protein binding	IBA	J:265628
Molecular Function	GO:0030165	PDZ domain binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:245291
Molecular Function	GO:0005515	protein binding	IPI	J:200384
Molecular Function	GO:0005515	protein binding	IPI	J:243475
Molecular Function	GO:0005515	protein binding	IPI	J:298861
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:164563
Molecular Function	GO:0038023	signaling receptor activity	ISO	J:155856
Molecular Function	GO:0038023	signaling receptor activity	IBA	J:265628
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0009986	cell surface	IDA	J:243525
Cellular Component	GO:0009986	cell surface	IBA	J:265628
Cellular Component	GO:0009986	cell surface	IDA	J:201692
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0043198	dendritic shaft	ISO	J:155856
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0060076	excitatory synapse	IC	J:138036
Cellular Component	GO:0060076	excitatory synapse	IC	J:116404
Cellular Component	GO:0060076	excitatory synapse	NAS	J:138036
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:161514
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0032433	filopodium tip	ISO	J:155856
Cellular Component	GO:0098982	GABA-ergic synapse	NAS	J:319984
Cellular Component	GO:0098978	glutamatergic synapse	NAS	J:319984
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:175189
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:175189
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:175189
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0060077	inhibitory synapse	NAS	J:138036
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0031594	neuromuscular junction	NAS	J:320287
Cellular Component	GO:0098984	neuron to neuron synapse	NAS	J:319989
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IMP	J:116404
Cellular Component	GO:0099634	postsynaptic specialization membrane	ISO	J:155856
Cellular Component	GO:0099634	postsynaptic specialization membrane	ISO	J:155856
Cellular Component	GO:0098635	protein complex involved in cell-cell adhesion	EXP	J:245291
Cellular Component	GO:0098635	protein complex involved in cell-cell adhesion	ISO	J:164563
Cellular Component	GO:0043235	receptor complex	IDA	J:84070
Cellular Component	GO:0045202	synapse	ISO	J:155856
Cellular Component	GO:0045202	synapse	IBA	J:265628
Cellular Component	GO:0045202	synapse	IDA	J:78720
Cellular Component	GO:0045202	synapse	IDA	J:96464
Biological Process	GO:0097113	AMPA glutamate receptor clustering	ISO	J:155856
Biological Process	GO:0097113	AMPA glutamate receptor clustering	IMP	J:184102
Biological Process	GO:0097113	AMPA glutamate receptor clustering	IDA	J:84070
Biological Process	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	NAS	J:245291
Biological Process	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	ISO	J:155856
Biological Process	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IDA	J:84070
Biological Process	GO:0007155	cell adhesion	IEA	J:60000
Biological Process	GO:0007155	cell adhesion	IEA	J:72247
Biological Process	GO:0090125	cell-cell adhesion involved in synapse maturation	NAS	J:319989
Biological Process	GO:0071277	cellular response to calcium ion	ISO	J:155856
Biological Process	GO:0007268	chemical synaptic transmission	IBA	J:265628
Biological Process	GO:0048789	cytoskeletal matrix organization at active zone	ISO	J:155856
Biological Process	GO:0048789	cytoskeletal matrix organization at active zone	IMP	J:152008
Biological Process	GO:0045184	establishment of protein localization	IMP	J:84070
Biological Process	GO:1904861	excitatory synapse assembly	IDA	J:232984
Biological Process	GO:1904861	excitatory synapse assembly	IMP	J:243525
Biological Process	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IDA	J:84070
Biological Process	GO:0060291	long-term synaptic potentiation	ISO	J:155856
Biological Process	GO:0099558	maintenance of synapse structure	NAS	J:319951
Biological Process	GO:0050804	modulation of chemical synaptic transmission	ISO	J:155856
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IBA	J:265628
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IGI	J:113647
Biological Process	GO:0061002	negative regulation of dendritic spine morphogenesis	IMP	J:197488
Biological Process	GO:0061002	negative regulation of dendritic spine morphogenesis	ISO	J:164563
Biological Process	GO:0007399	nervous system development	IDA	J:116404
Biological Process	GO:0007399	nervous system development	ISO	J:164563
Biological Process	GO:0007399	nervous system development	IMP	J:247060
Biological Process	GO:0097115	neurexin clustering involved in presynaptic membrane assembly	IDA	J:84070
Biological Process	GO:0007158	neuron cell-cell adhesion	ISO	J:155856
Biological Process	GO:0007158	neuron cell-cell adhesion	IDA	J:84070
Biological Process	GO:0007158	neuron cell-cell adhesion	NAS	J:319989
Biological Process	GO:0007158	neuron cell-cell adhesion	IBA	J:265628
Biological Process	GO:0140058	neuron projection arborization	ISO	J:155856
Biological Process	GO:0031175	neuron projection development	ISO	J:155856
Biological Process	GO:0031175	neuron projection development	ISO	J:164563
Biological Process	GO:0048812	neuron projection morphogenesis	NAS	J:319951
Biological Process	GO:0097114	NMDA glutamate receptor clustering	ISO	J:155856
Biological Process	GO:0010841	positive regulation of circadian sleep/wake cycle, wakefulness	IMP	J:197398
Biological Process	GO:0060999	positive regulation of dendritic spine development	IMP	J:197488
Biological Process	GO:0060999	positive regulation of dendritic spine development	ISO	J:155856
Biological Process	GO:0060999	positive regulation of dendritic spine development	ISO	J:164563
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	ISO	J:164563
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	IMP	J:197488
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	ISO	J:155856
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	IDA	J:138036
Biological Process	GO:0051491	positive regulation of filopodium assembly	ISO	J:155856
Biological Process	GO:1902533	positive regulation of intracellular signal transduction	ISO	J:155856
Biological Process	GO:1900075	positive regulation of neuromuscular synaptic transmission	NAS	J:320287
Biological Process	GO:0010976	positive regulation of neuron projection development	NAS	J:319951
Biological Process	GO:1905520	positive regulation of presynaptic active zone assembly	ISO	J:155856
Biological Process	GO:1902474	positive regulation of protein localization to synapse	ISO	J:155856
Biological Process	GO:1900029	positive regulation of ruffle assembly	ISO	J:155856
Biological Process	GO:0051965	positive regulation of synapse assembly	ISO	J:155856
Biological Process	GO:0051965	positive regulation of synapse assembly	IDA	J:171950
Biological Process	GO:0051965	positive regulation of synapse assembly	ISO	J:211830
Biological Process	GO:0032230	positive regulation of synaptic transmission, GABAergic	ISO	J:155856
Biological Process	GO:0032230	positive regulation of synaptic transmission, GABAergic	NAS	J:319984
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	NAS	J:319984
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	ISO	J:155856
Biological Process	GO:2000809	positive regulation of synaptic vesicle clustering	IDA	J:175189
Biological Process	GO:1900244	positive regulation of synaptic vesicle endocytosis	ISO	J:155856
Biological Process	GO:1900244	positive regulation of synaptic vesicle endocytosis	IMP	J:152008
Biological Process	GO:2000302	positive regulation of synaptic vesicle exocytosis	IMP	J:152008
Biological Process	GO:2000302	positive regulation of synaptic vesicle exocytosis	ISO	J:155856
Biological Process	GO:0097119	postsynaptic density protein 95 clustering	IDA	J:180545
Biological Process	GO:0097119	postsynaptic density protein 95 clustering	IDA	J:84070
Biological Process	GO:0097119	postsynaptic density protein 95 clustering	ISO	J:155856
Biological Process	GO:0097119	postsynaptic density protein 95 clustering	IDA	J:175189
Biological Process	GO:0097104	postsynaptic membrane assembly	IDA	J:175189
Biological Process	GO:0097104	postsynaptic membrane assembly	IDA	J:84070
Biological Process	GO:0097104	postsynaptic membrane assembly	IBA	J:265628
Biological Process	GO:0098698	postsynaptic specialization assembly	IDA	J:175189
Biological Process	GO:0098698	postsynaptic specialization assembly	IDA	J:175189
Biological Process	GO:0098698	postsynaptic specialization assembly	IMP	J:175189
Biological Process	GO:0097105	presynaptic membrane assembly	ISO	J:155856
Biological Process	GO:0097105	presynaptic membrane assembly	IDA	J:116404
Biological Process	GO:0097105	presynaptic membrane assembly	IDA	J:175189
Biological Process	GO:0097105	presynaptic membrane assembly	IDA	J:84070
Biological Process	GO:0097105	presynaptic membrane assembly	IBA	J:265628
Biological Process	GO:0035418	protein localization to synapse	IDA	J:175189
Biological Process	GO:0035418	protein localization to synapse	IDA	J:232984
Biological Process	GO:0006605	protein targeting	ISO	J:155856
Biological Process	GO:0097120	receptor localization to synapse	IDA	J:84070
Biological Process	GO:2000311	regulation of AMPA receptor activity	ISO	J:155856
Biological Process	GO:0045664	regulation of neuron differentiation	IDA	J:116404
Biological Process	GO:2000310	regulation of NMDA receptor activity	IDA	J:138036
Biological Process	GO:2000310	regulation of NMDA receptor activity	IMP	J:197488
Biological Process	GO:2000310	regulation of NMDA receptor activity	ISO	J:164563
Biological Process	GO:2000310	regulation of NMDA receptor activity	ISO	J:155856
Biological Process	GO:0099174	regulation of presynapse organization	ISO	J:155856
Biological Process	GO:0002087	regulation of respiratory gaseous exchange by nervous system process	IGI	J:113647
Biological Process	GO:0098942	retrograde trans-synaptic signaling by trans-synaptic protein complex	ISO	J:155856
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0007416	synapse assembly	IDA	J:116404
Biological Process	GO:0007416	synapse assembly	NAS	J:319989
Biological Process	GO:0007416	synapse assembly	ISO	J:155856
Biological Process	GO:0007416	synapse assembly	IDA	J:171950
Biological Process	GO:0007416	synapse assembly	IDA	J:171950
Biological Process	GO:0060074	synapse maturation	NAS	J:319989
Biological Process	GO:0050808	synapse organization	IGI	J:176974
Biological Process	GO:0050808	synapse organization	IGI	J:176974
Biological Process	GO:0050808	synapse organization	IGI	J:176974
Biological Process	GO:0050808	synapse organization	ISO	J:96464
Biological Process	GO:0099560	synaptic membrane adhesion	IMP	J:230665
Biological Process	GO:0099560	synaptic membrane adhesion	IDA	J:84070
Biological Process	GO:0099560	synaptic membrane adhesion	IMP	J:84070
Biological Process	GO:0099560	synaptic membrane adhesion	IDA	J:84070
Biological Process	GO:0097091	synaptic vesicle clustering	IDA	J:116404
Biological Process	GO:0097091	synaptic vesicle clustering	ISO	J:155856
Biological Process	GO:0097091	synaptic vesicle clustering	IDA	J:84070
Biological Process	GO:0048488	synaptic vesicle endocytosis	IBA	J:265628
Biological Process	GO:0016080	synaptic vesicle targeting	IMP	J:116404
Biological Process	GO:0048489	synaptic vesicle transport	ISO	J:155856
Biological Process	GO:0072553	terminal button organization	IMP	J:152008
Biological Process	GO:0072553	terminal button organization	ISO	J:155856

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24