GO Annotations Graph

• Symbol: Edem1
• Name: ER degradation enhancer, mannosidase alpha-like 1
• ID: MGI:2180139

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	IMP	J:222679
Molecular Function	GO:0051787	misfolded protein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:170851
Molecular Function	GO:0005515	protein binding	IPI	J:208389
Cellular Component	GO:0016235	aggresome	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IBA	J:265628
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:73065
Cellular Component	GO:0005789	endoplasmic reticulum membrane	IDA	J:76183
Cellular Component	GO:0044322	endoplasmic reticulum quality control compartment	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Biological Process	GO:0005975	carbohydrate metabolic process	IEA	J:72247
Biological Process	GO:1904380	endoplasmic reticulum mannose trimming	IBA	J:265628
Biological Process	GO:1904382	mannose trimming involved in glycoprotein ERAD pathway	ISO	J:164563
Biological Process	GO:1904382	mannose trimming involved in glycoprotein ERAD pathway	IBA	J:265628
Biological Process	GO:1904154	positive regulation of retrograde protein transport, ER to cytosol	IDA	J:208389
Biological Process	GO:1904154	positive regulation of retrograde protein transport, ER to cytosol	ISO	J:164563
Biological Process	GO:0045047	protein targeting to ER	ISO	J:164563
Biological Process	GO:0006986	response to unfolded protein	IEA	J:60000
Biological Process	GO:0036510	trimming of terminal mannose on C branch	IMP	J:222679
Biological Process	GO:0030433	ubiquitin-dependent ERAD pathway	IDA	J:76183
Biological Process	GO:0097466	ubiquitin-dependent glycoprotein ERAD pathway	ISO	J:164563