GO Annotations Graph

• Symbol: Slc8b1
• Name: solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
• ID: MGI:2180781

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0015297	antiporter activity	IEA	J:60000
Molecular Function	GO:0005432	calcium:sodium antiporter activity	ISO	J:164563
Molecular Function	GO:0005432	calcium:sodium antiporter activity	IDA	J:156453
Molecular Function	GO:0005432	calcium:sodium antiporter activity	IMP	J:241501
Molecular Function	GO:0005432	calcium:sodium antiporter activity	IBA	J:265628
Molecular Function	GO:0005432	calcium:sodium antiporter activity	IDA	J:88504
Molecular Function	GO:0086038	calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential	IC	J:156453
Molecular Function	GO:0086038	calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential	IMP	J:241501
Molecular Function	GO:0086038	calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential	IMP	J:241472
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:155856
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	IPI	J:156453
Cellular Component	GO:0016020	membrane	IBA	J:265628
Cellular Component	GO:0030061	mitochondrial crista	ISS	J:156453
Cellular Component	GO:0030061	mitochondrial crista	ISO	J:164563
Cellular Component	GO:0030061	mitochondrial crista	ISO	J:155856
Cellular Component	GO:0005743	mitochondrial inner membrane	ISO	J:73065
Cellular Component	GO:0031966	mitochondrial membrane	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IDA	J:241472
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IDA	J:156453
Cellular Component	GO:0005739	mitochondrion	IDA	J:156453
Cellular Component	GO:0005886	plasma membrane	IDA	J:88504
Cellular Component	GO:0042383	sarcolemma	ISO	J:73065
Biological Process	GO:0099093	calcium export from the mitochondrion	ISO	J:164563
Biological Process	GO:0099093	calcium export from the mitochondrion	IMP	J:241501
Biological Process	GO:0099093	calcium export from the mitochondrion	IMP	J:241472
Biological Process	GO:0099093	calcium export from the mitochondrion	IBA	J:265628
Biological Process	GO:0070588	calcium ion transmembrane transport	IDA	J:88504
Biological Process	GO:0006816	calcium ion transport	IEA	J:60000
Biological Process	GO:0042593	glucose homeostasis	ISO	J:164563
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IBA	J:265628
Biological Process	GO:0051560	mitochondrial calcium ion homeostasis	IMP	J:241501
Biological Process	GO:0051560	mitochondrial calcium ion homeostasis	IDA	J:156453
Biological Process	GO:0051560	mitochondrial calcium ion homeostasis	ISO	J:164563
Biological Process	GO:0006851	mitochondrial calcium ion transmembrane transport	IMP	J:241501
Biological Process	GO:0006851	mitochondrial calcium ion transmembrane transport	ISO	J:73065
Biological Process	GO:0006851	mitochondrial calcium ion transmembrane transport	IDA	J:156453
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0086036	regulation of cardiac muscle cell membrane potential	IC	J:156453
Biological Process	GO:0051480	regulation of cytosolic calcium ion concentration	ISO	J:164563
Biological Process	GO:0051480	regulation of cytosolic calcium ion concentration	IDA	J:156453
Biological Process	GO:0050796	regulation of insulin secretion	ISO	J:164563
Biological Process	GO:1901623	regulation of lymphocyte chemotaxis	IMP	J:241464
Biological Process	GO:2001256	regulation of store-operated calcium entry	ISO	J:164563
Biological Process	GO:0050896	response to stimulus	IEA	J:60000
Biological Process	GO:0035725	sodium ion transmembrane transport	IDA	J:88504
Biological Process	GO:0006814	sodium ion transport	IEA	J:60000
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247