GO Annotations Graph

• Symbol: Trpm8
• Name: transient receptor potential cation channel, subfamily M, member 8
• ID: MGI:2181435

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005262	calcium channel activity	IDA	J:117484
Molecular Function	GO:0005262	calcium channel activity	IDA	J:96171
Molecular Function	GO:0005262	calcium channel activity	IMP	J:122978
Molecular Function	GO:0005262	calcium channel activity	IDA	J:76188
Molecular Function	GO:0042802	identical protein binding	IPI	J:117484
Molecular Function	GO:0099604	ligand-gated calcium channel activity	IBA	J:265628
Molecular Function	GO:0005216	monoatomic ion channel activity	ISO	J:155856
Molecular Function	GO:0005216	monoatomic ion channel activity	IDA	J:92550
Molecular Function	GO:0005515	protein binding	IPI	J:223963
Molecular Function	GO:0005515	protein binding	IPI	J:145300
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:117484
Cellular Component	GO:0016020	membrane	IDA	J:76188
Cellular Component	GO:0016020	membrane	ISS	J:96171
Cellular Component	GO:0005886	plasma membrane	ISO	J:223963
Biological Process	GO:0070588	calcium ion transmembrane transport	IBA	J:265628
Biological Process	GO:0006816	calcium ion transport	IDA	J:117484
Biological Process	GO:0016048	detection of temperature stimulus	IEA	J:72247
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IDA	J:76188
Biological Process	GO:0006812	monoatomic cation transport	IEA	J:72247
Biological Process	GO:0034220	monoatomic ion transmembrane transport	IDA	J:92550
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:249902
Biological Process	GO:0009409	response to cold	ISO	J:155856
Biological Process	GO:0009409	response to cold	IDA	J:117484
Biological Process	GO:0009409	response to cold	IMP	J:122956
Biological Process	GO:0009409	response to cold	IDA	J:96171
Biological Process	GO:0009409	response to cold	IMP	J:122978
Biological Process	GO:0009409	response to cold	IMP	J:122963
Biological Process	GO:0050896	response to stimulus	IEA	J:60000
Biological Process	GO:0009266	response to temperature stimulus	IDA	J:76188
Biological Process	GO:0050951	sensory perception of temperature stimulus	IEA	J:72247
Biological Process	GO:0050955	thermoception	IMP	J:122978
Biological Process	GO:0050955	thermoception	IMP	J:122963
Biological Process	GO:0050955	thermoception	IMP	J:122956
Biological Process	GO:0050955	thermoception	IDA	J:96171