GO Annotations Graph

• Symbol: Hectd1
• Name: HECT domain E3 ubiquitin protein ligase 1
• ID: MGI:2384768

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0046872	metal ion binding	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:185047
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0061630	ubiquitin protein ligase activity	ISO	J:164563
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IBA	J:265628
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IDA	J:185047
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	IEA	J:72247
Cellular Component	GO:0016607	nuclear speck	IBA	J:265628
Biological Process	GO:0048856	anatomical structure development	IBA	J:265628
Biological Process	GO:0035904	aorta development	IMP	J:222159
Biological Process	GO:0001892	embryonic placenta development	IMP	J:215001
Biological Process	GO:0001892	embryonic placenta development	IMP	J:215001
Biological Process	GO:0003170	heart valve development	IMP	J:222159
Biological Process	GO:0001779	natural killer cell differentiation	IMP	J:215001
Biological Process	GO:1903077	negative regulation of protein localization to plasma membrane	IMP	J:185047
Biological Process	GO:1903077	negative regulation of protein localization to plasma membrane	IMP	J:185047
Biological Process	GO:0001843	neural tube closure	IMP	J:122594
Biological Process	GO:0001843	neural tube closure	IMP	J:98216
Biological Process	GO:0001843	neural tube closure	IMP	J:48268
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IBA	J:265628
Biological Process	GO:0051865	protein autoubiquitination	IMP	J:185047
Biological Process	GO:0070534	protein K63-linked ubiquitination	IBA	J:265628
Biological Process	GO:0070534	protein K63-linked ubiquitination	IMP	J:185047
Biological Process	GO:0070534	protein K63-linked ubiquitination	IDA	J:185047
Biological Process	GO:0070534	protein K63-linked ubiquitination	IMP	J:185047
Biological Process	GO:0070534	protein K63-linked ubiquitination	IMP	J:185047
Biological Process	GO:0070534	protein K63-linked ubiquitination	IDA	J:185047
Biological Process	GO:0072659	protein localization to plasma membrane	IMP	J:185047
Biological Process	GO:0072659	protein localization to plasma membrane	IMP	J:185047
Biological Process	GO:0016567	protein ubiquitination	IEA	J:72247
Biological Process	GO:0060708	spongiotrophoblast differentiation	IMP	J:215001
Biological Process	GO:0060707	trophoblast giant cell differentiation	IMP	J:215001
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IEA	J:72247
Biological Process	GO:0003281	ventricular septum development	IMP	J:222159