GO Annotations Graph

• Symbol: Eif2b1
• Name: eukaryotic translation initiation factor 2B, subunit alpha
• ID: MGI:2384802

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019003	GDP binding	ISO	J:155856
Molecular Function	GO:0005525	GTP binding	ISO	J:155856
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ISO	J:155856
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ISO	J:164563
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IBA	J:265628
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ISO	J:73065
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:97384
Molecular Function	GO:0003743	translation initiation factor activity	ISO	J:155856
Molecular Function	GO:0003743	translation initiation factor activity	ISO	J:164563
Molecular Function	GO:0003743	translation initiation factor activity	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:41995
Cellular Component	GO:0005850	eukaryotic translation initiation factor 2 complex	ISO	J:155856
Cellular Component	GO:0005851	eukaryotic translation initiation factor 2B complex	ISO	J:164563
Cellular Component	GO:0005851	eukaryotic translation initiation factor 2B complex	ISO	J:155856
Cellular Component	GO:0005851	eukaryotic translation initiation factor 2B complex	IBA	J:265628
Cellular Component	GO:0005851	eukaryotic translation initiation factor 2B complex	ISO	J:73065
Cellular Component	GO:0016020	membrane	ISO	J:41995
Cellular Component	GO:0005886	plasma membrane	ISO	J:41995
Biological Process	GO:0044237	cellular metabolic process	IEA	J:72247
Biological Process	GO:1905098	negative regulation of guanyl-nucleotide exchange factor activity	ISO	J:155856
Biological Process	GO:0014003	oligodendrocyte development	ISO	J:164563
Biological Process	GO:1990928	response to amino acid starvation	ISO	J:155856
Biological Process	GO:0009749	response to glucose	ISO	J:155856
Biological Process	GO:0009408	response to heat	ISO	J:155856
Biological Process	GO:0043434	response to peptide hormone	ISO	J:155856
Biological Process	GO:0050852	T cell receptor signaling pathway	ISO	J:164563
Biological Process	GO:0006412	translation	ISO	J:155856
Biological Process	GO:0006413	translational initiation	ISO	J:164563
Biological Process	GO:0006413	translational initiation	ISO	J:155856
Biological Process	GO:0006413	translational initiation	IBA	J:265628