GO Annotations Graph

• Symbol: Cdc73
• Name: cell division cycle 73, Paf1/RNA polymerase II complex component
• ID: MGI:2384876

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005515	protein binding	IPI	J:283190
Molecular Function	GO:0005515	protein binding	IPI	J:237500
Molecular Function	GO:0005515	protein binding	IPI	J:183708
Molecular Function	GO:0000993	RNA polymerase II complex binding	ISO	J:164563
Molecular Function	GO:0000993	RNA polymerase II complex binding	IBA	J:265628
Cellular Component	GO:0016593	Cdc73/Paf1 complex	ISO	J:164563
Cellular Component	GO:0016593	Cdc73/Paf1 complex	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IDA	J:183965
Biological Process	GO:0001711	endodermal cell fate commitment	IMP	J:149841
Biological Process	GO:0016570	histone modification	IEA	J:72247
Biological Process	GO:0006378	mRNA polyadenylation	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:135255
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	ISO	J:164563
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	ISO	J:164563
Biological Process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0045638	negative regulation of myeloid cell differentiation	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:149841
Biological Process	GO:1902808	positive regulation of cell cycle G1/S phase transition	ISO	J:164563
Biological Process	GO:0031442	positive regulation of mRNA 3'-end processing	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0032968	positive regulation of transcription elongation by RNA polymerase II	IBA	J:265628
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0031648	protein destabilization	ISO	J:164563
Biological Process	GO:0034402	recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex	IBA	J:265628
Biological Process	GO:0001558	regulation of cell growth	IMP	J:135255
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IMP	J:135255
Biological Process	GO:0019827	stem cell population maintenance	IMP	J:149841
Biological Process	GO:0006368	transcription elongation by RNA polymerase II	ISO	J:164563
Biological Process	GO:0016055	Wnt signaling pathway	IEA	J:60000