GO Annotations Graph

• Symbol: Appl2
• Name: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
• ID: MGI:2384914

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0035091	phosphatidylinositol binding	ISO	J:164563
Molecular Function	GO:0001786	phosphatidylserine binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:156351
Molecular Function	GO:0005515	protein binding	IPI	J:230004
Molecular Function	GO:0005515	protein binding	IPI	J:268015
Molecular Function	GO:0005515	protein binding	IPI	J:230004
Molecular Function	GO:0005515	protein binding	IPI	J:226873
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Molecular Function	GO:0031267	small GTPase binding	ISO	J:73065
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IDA	J:156351
Cellular Component	GO:0005737	cytoplasm	IDA	J:268015
Cellular Component	GO:0005737	cytoplasm	ISO	J:73065
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:164563
Cellular Component	GO:0032009	early phagosome	IDA	J:268015
Cellular Component	GO:0036186	early phagosome membrane	IDA	J:268007
Cellular Component	GO:0005768	endosome	ISO	J:164563
Cellular Component	GO:0010008	endosome membrane	ISO	J:164563
Cellular Component	GO:0010008	endosome membrane	IBA	J:265628
Cellular Component	GO:0044354	macropinosome	IDA	J:268007
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:73065
Cellular Component	GO:0005886	plasma membrane	IDA	J:268007
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0001726	ruffle	IDA	J:268015
Cellular Component	GO:0032587	ruffle membrane	IDA	J:268007
Cellular Component	GO:0031982	vesicle	ISO	J:164563
Biological Process	GO:0033211	adiponectin-activated signaling pathway	IMP	J:156351
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0008283	cell population proliferation	ISO	J:73065
Biological Process	GO:0035729	cellular response to hepatocyte growth factor stimulus	IMP	J:227340
Biological Process	GO:0009631	cold acclimation	IMP	J:261013
Biological Process	GO:0002024	diet induced thermogenesis	IMP	J:261013
Biological Process	GO:0042593	glucose homeostasis	ISO	J:164563
Biological Process	GO:1900077	negative regulation of cellular response to insulin stimulus	IMP	J:156351
Biological Process	GO:1900016	negative regulation of cytokine production involved in inflammatory response	IMP	J:226873
Biological Process	GO:0046322	negative regulation of fatty acid oxidation	IMP	J:156351
Biological Process	GO:0046325	negative regulation of glucose import	ISO	J:164563
Biological Process	GO:0046325	negative regulation of glucose import	IMP	J:156351
Biological Process	GO:2000178	negative regulation of neural precursor cell proliferation	IMP	J:268033
Biological Process	GO:0050768	negative regulation of neurogenesis	IMP	J:268172
Biological Process	GO:0050768	negative regulation of neurogenesis	IMP	J:268033
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:261013
Biological Process	GO:1905451	positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis	IMP	J:268015
Biological Process	GO:1905303	positive regulation of macropinocytosis	IMP	J:268007
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment	IMP	J:268015
Biological Process	GO:0051289	protein homotetramerization	ISO	J:164563
Biological Process	GO:0006606	protein import into nucleus	ISO	J:164563
Biological Process	GO:0010762	regulation of fibroblast migration	IMP	J:227340
Biological Process	GO:2000045	regulation of G1/S transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0045088	regulation of innate immune response	IMP	J:268007
Biological Process	GO:0034143	regulation of toll-like receptor 4 signaling pathway	IMP	J:268007
Biological Process	GO:0023052	signaling	IBA	J:265628
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:164563