GO Annotations Graph

• Symbol: Fermt2
• Name: fermitin family member 2
• ID: MGI:2385001

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	ISO	J:164563
Molecular Function	GO:0051015	actin filament binding	IDA	J:114381
Molecular Function	GO:0051015	actin filament binding	IDA	J:114381
Molecular Function	GO:0005178	integrin binding	IBA	J:265628
Molecular Function	GO:0008289	lipid binding	IEA	J:60000
Molecular Function	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0046332	SMAD binding	ISO	J:164563
Molecular Function	GO:0034713	type I transforming growth factor beta receptor binding	ISO	J:164563
Cellular Component	GO:0005912	adherens junction	ISO	J:164563
Cellular Component	GO:0030054	cell junction	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	ISO	J:164563
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	IBA	J:265628
Cellular Component	GO:0005925	focal adhesion	ISO	J:164563
Cellular Component	GO:0005925	focal adhesion	IBA	J:265628
Cellular Component	GO:0005925	focal adhesion	ISO	J:254431
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0001725	stress fiber	IDA	J:114381
Cellular Component	GO:0001725	stress fiber	IDA	J:114381
Biological Process	GO:0034334	adherens junction maintenance	ISO	J:164563
Biological Process	GO:0034334	adherens junction maintenance	IMP	J:296110
Biological Process	GO:0007155	cell adhesion	ISO	J:164563
Biological Process	GO:0007160	cell-matrix adhesion	IMP	J:134768
Biological Process	GO:0007160	cell-matrix adhesion	ISO	J:164563
Biological Process	GO:0007160	cell-matrix adhesion	IBA	J:265628
Biological Process	GO:0048041	focal adhesion assembly	IMP	J:134768
Biological Process	GO:0048041	focal adhesion assembly	ISO	J:164563
Biological Process	GO:0033622	integrin activation	ISO	J:164563
Biological Process	GO:0033622	integrin activation	IMP	J:134768
Biological Process	GO:0007229	integrin-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0060173	limb development	IMP	J:260481
Biological Process	GO:0060548	negative regulation of cell death	ISO	J:164563
Biological Process	GO:0045599	negative regulation of fat cell differentiation	ISO	J:164563
Biological Process	GO:0045599	negative regulation of fat cell differentiation	IMP	J:260481
Biological Process	GO:0043116	negative regulation of vascular permeability	ISO	J:164563
Biological Process	GO:0043116	negative regulation of vascular permeability	IMP	J:296110
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0051894	positive regulation of focal adhesion assembly	ISO	J:164563
Biological Process	GO:0043547	positive regulation of GTPase activity	ISO	J:164563
Biological Process	GO:0033625	positive regulation of integrin activation	ISO	J:164563
Biological Process	GO:1902462	positive regulation of mesenchymal stem cell proliferation	ISO	J:164563
Biological Process	GO:0035505	positive regulation of myosin light chain kinase activity	ISO	J:164563
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	IMP	J:260481
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	ISO	J:164563
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	ISO	J:164563
Biological Process	GO:0051496	positive regulation of stress fiber assembly	ISO	J:164563
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	ISO	J:164563
Biological Process	GO:1903691	positive regulation of wound healing, spreading of epidermal cells	ISO	J:164563
Biological Process	GO:1902414	protein localization to cell junction	ISO	J:164563
Biological Process	GO:0072657	protein localization to membrane	IMP	J:134768
Biological Process	GO:0022604	regulation of cell morphogenesis	ISO	J:164563
Biological Process	GO:0008360	regulation of cell shape	IEA	J:60000
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	IMP	J:134768
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0016055	Wnt signaling pathway	ISO	J:164563