GO Annotations Graph

• Symbol: Tpcn2
• Name: two pore segment channel 2
• ID: MGI:2385297

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005262	calcium channel activity	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0097682	intracellular phosphatidylinositol-3,5-bisphosphate-sensitive monatomic cation channel activity	ISO	J:164563
Molecular Function	GO:0097682	intracellular phosphatidylinositol-3,5-bisphosphate-sensitive monatomic cation channel activity	IBA	J:265628
Molecular Function	GO:0015280	ligand-gated sodium channel activity	ISO	J:164563
Molecular Function	GO:0015280	ligand-gated sodium channel activity	IDA	J:328828
Molecular Function	GO:0015280	ligand-gated sodium channel activity	IBA	J:265628
Molecular Function	GO:0005216	monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0072345	NAADP-sensitive calcium-release channel activity	IDA	J:175352
Molecular Function	GO:0072345	NAADP-sensitive calcium-release channel activity	IMP	J:225206
Molecular Function	GO:0072345	NAADP-sensitive calcium-release channel activity	IMP	J:175340
Molecular Function	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0005245	voltage-gated calcium channel activity	IMP	J:175340
Molecular Function	GO:0022832	voltage-gated channel activity	IEA	J:72247
Molecular Function	GO:0005244	voltage-gated monoatomic ion channel activity	IEA	J:60000
Cellular Component	GO:0036020	endolysosome membrane	ISO	J:164563
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0010008	endosome membrane	ISO	J:164563
Cellular Component	GO:0005765	lysosomal membrane	IDA	J:306599
Cellular Component	GO:0005765	lysosomal membrane	IDA	J:175352
Cellular Component	GO:0005765	lysosomal membrane	ISO	J:164563
Cellular Component	GO:0005765	lysosomal membrane	IBA	J:265628
Cellular Component	GO:0005764	lysosome	IDA	J:175340
Cellular Component	GO:0005764	lysosome	IDA	J:225206
Cellular Component	GO:0005764	lysosome	ISO	J:164563
Cellular Component	GO:0033162	melanosome membrane	IDA	J:328828
Cellular Component	GO:0033162	melanosome membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Biological Process	GO:0070588	calcium ion transmembrane transport	IEA	J:60000
Biological Process	GO:0006816	calcium ion transport	IEA	J:60000
Biological Process	GO:0019722	calcium-mediated signaling	ISO	J:164563
Biological Process	GO:0019722	calcium-mediated signaling	IMP	J:225206
Biological Process	GO:0019722	calcium-mediated signaling	IBA	J:265628
Biological Process	GO:0075509	endocytosis involved in viral entry into host cell	ISO	J:164563
Biological Process	GO:0075509	endocytosis involved in viral entry into host cell	IMP	J:306587
Biological Process	GO:0075509	endocytosis involved in viral entry into host cell	IBA	J:265628
Biological Process	GO:0090117	endosome to lysosome transport of low-density lipoprotein particle	IMP	J:225206
Biological Process	GO:0006874	intracellular calcium ion homeostasis	ISO	J:164563
Biological Process	GO:0051452	intracellular pH reduction	ISO	J:164563
Biological Process	GO:0051452	intracellular pH reduction	IDA	J:328828
Biological Process	GO:0007040	lysosome organization	ISO	J:164563
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0048086	negative regulation of developmental pigmentation	IDA	J:328828
Biological Process	GO:0048086	negative regulation of developmental pigmentation	ISO	J:164563
Biological Process	GO:0019065	receptor-mediated endocytosis of virus by host cell	ISO	J:164563
Biological Process	GO:0010506	regulation of autophagy	ISO	J:164563
Biological Process	GO:0017157	regulation of exocytosis	IMP	J:306599
Biological Process	GO:0034765	regulation of monoatomic ion transmembrane transport	IEA	J:60000
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	IMP	J:175340
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	IMP	J:225206
Biological Process	GO:0006939	smooth muscle contraction	IMP	J:165894
Biological Process	GO:0035725	sodium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247