GO Annotations Graph

• Symbol: Socs5
• Name: suppressor of cytokine signaling 5
• ID: MGI:2385459

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	IBA	J:265628
Molecular Function	GO:0005154	epidermal growth factor receptor binding	IPI	J:96642
Molecular Function	GO:0019210	kinase inhibitor activity	NAS	J:51029
Molecular Function	GO:0005515	protein binding	IPI	J:113957
Molecular Function	GO:0030971	receptor tyrosine kinase binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	NAS	J:113957
Cellular Component	GO:0005942	phosphatidylinositol 3-kinase complex	IBA	J:265628
Biological Process	GO:0071404	cellular response to low-density lipoprotein particle stimulus	IMP	J:223623
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IDA	J:113957
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IDA	J:96642
Biological Process	GO:0035556	intracellular signal transduction	IEA	J:72247
Biological Process	GO:1904988	negative regulation of endothelial cell activation	IC	J:223623
Biological Process	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity	ISO	J:164563
Biological Process	GO:0050728	negative regulation of inflammatory response	IMP	J:223623
Biological Process	GO:0032715	negative regulation of interleukin-6 production	IMP	J:223623
Biological Process	GO:0071638	negative regulation of monocyte chemotactic protein-1 production	IMP	J:223623
Biological Process	GO:0009968	negative regulation of signal transduction	NAS	J:113957
Biological Process	GO:0045629	negative regulation of T-helper 2 cell differentiation	IDA	J:113957
Biological Process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	IBA	J:265628
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0045627	positive regulation of T-helper 1 cell differentiation	IDA	J:113957
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	TAS	J:113957
Biological Process	GO:0040008	regulation of growth	IEA	J:60000
Biological Process	GO:0097699	vascular endothelial cell response to fluid shear stress	IMP	J:223623