GO Annotations Graph

• Symbol: Sirt7
• Name: sirtuin 7
• ID: MGI:2385849

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0070403	NAD+ binding	IEA	J:72247
Molecular Function	GO:0097372	NAD-dependent histone H3K18 deacetylase activity	ISO	J:164563
Molecular Function	GO:0097372	NAD-dependent histone H3K18 deacetylase activity	IMP	J:281207
Molecular Function	GO:0097372	NAD-dependent histone H3K18 deacetylase activity	IMP	J:234105
Molecular Function	GO:0097372	NAD-dependent histone H3K18 deacetylase activity	IBA	J:265628
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	IDA	J:277821
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	ISO	J:164563
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	IDA	J:272987
Molecular Function	GO:0005515	protein binding	IPI	J:272987
Molecular Function	GO:0033558	protein lysine deacetylase activity	IEA	J:72245
Molecular Function	GO:0008276	protein methyltransferase activity	ISO	J:164563
Molecular Function	GO:0061697	protein-glutaryllysine deglutarylase activity	ISO	J:164563
Molecular Function	GO:0106231	protein-propionyllysine depropionylase activity	IDA	J:266247
Molecular Function	GO:0036055	protein-succinyllysine desuccinylase activity	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0000785	chromatin	IDA	J:281203
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0016607	nuclear speck	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005731	nucleolus organizer region	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0035861	site of double-strand break	IMP	J:234105
Cellular Component	GO:0035861	site of double-strand break	ISO	J:164563
Biological Process	GO:0006325	chromatin organization	IEA	J:60000
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0006281	DNA repair	IEA	J:60000
Biological Process	GO:0140861	DNA repair-dependent chromatin remodeling	IMP	J:234105
Biological Process	GO:0140861	DNA repair-dependent chromatin remodeling	ISO	J:164563
Biological Process	GO:0070932	histone H3 deacetylation	IBA	J:265628
Biological Process	GO:0007129	homologous chromosome pairing at meiosis	IMP	J:281207
Biological Process	GO:0045814	negative regulation of gene expression, epigenetic	IMP	J:281203
Biological Process	GO:0031397	negative regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0010529	negative regulation of transposition	IMP	J:281203
Biological Process	GO:0001649	osteoblast differentiation	IMP	J:266247
Biological Process	GO:0045722	positive regulation of gluconeogenesis	ISO	J:164563
Biological Process	GO:2000234	positive regulation of rRNA processing	ISO	J:164563
Biological Process	GO:0045943	positive regulation of transcription by RNA polymerase I	ISO	J:164563
Biological Process	GO:0007072	positive regulation of transcription involved in exit from mitosis	ISO	J:164563
Biological Process	GO:0006476	protein deacetylation	IDA	J:277821
Biological Process	GO:0006476	protein deacetylation	IDA	J:272987
Biological Process	GO:0006476	protein deacetylation	ISO	J:164563
Biological Process	GO:0061698	protein deglutarylation	ISO	J:164563
Biological Process	GO:0106230	protein depropionylation	IDA	J:266247
Biological Process	GO:0062176	R-loop processing	ISO	J:164563
Biological Process	GO:0006282	regulation of DNA repair	ISO	J:164563
Biological Process	GO:0010821	regulation of mitochondrion organization	IMP	J:272987
Biological Process	GO:0010821	regulation of mitochondrion organization	ISO	J:164563
Biological Process	GO:0046825	regulation of protein export from nucleus	IMP	J:277821
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:1901836	regulation of transcription of nucleolar large rRNA by RNA polymerase I	ISO	J:164563
Biological Process	GO:0009303	rRNA transcription	ISO	J:164563
Biological Process	GO:0045815	transcription initiation-coupled chromatin remodeling	ISO	J:164563