GO Annotations Graph

• Symbol: Zc3h12a
• Name: zinc finger CCCH type containing 12A
• ID: MGI:2385891

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	ISO	J:164563
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0004519	endonuclease activity	IEA	J:60000
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0035198	miRNA binding	ISO	J:164563
Molecular Function	GO:0035925	mRNA 3'-UTR AU-rich region binding	IDA	J:147868
Molecular Function	GO:0003730	mRNA 3'-UTR binding	IDA	J:229326
Molecular Function	GO:0003730	mRNA 3'-UTR binding	IDA	J:228409
Molecular Function	GO:0003730	mRNA 3'-UTR binding	IDA	J:228359
Molecular Function	GO:0003729	mRNA binding	ISO	J:164563
Molecular Function	GO:0003729	mRNA binding	EXP	J:326245
Molecular Function	GO:0003729	mRNA binding	IBA	J:265628
Molecular Function	GO:0004518	nuclease activity	IMP	J:259145
Molecular Function	GO:0005515	protein binding	IPI	J:229326
Molecular Function	GO:0005515	protein binding	IPI	J:228359
Molecular Function	GO:0005515	protein binding	IPI	J:179016
Molecular Function	GO:0043022	ribosome binding	IDA	J:229326
Molecular Function	GO:0003723	RNA binding	ISO	J:164563
Molecular Function	GO:0004521	RNA endonuclease activity	IDA	J:228359
Molecular Function	GO:0004521	RNA endonuclease activity	IDA	J:228411
Molecular Function	GO:0004521	RNA endonuclease activity	IDA	J:229326
Molecular Function	GO:0004521	RNA endonuclease activity	IBA	J:265628
Molecular Function	GO:0004532	RNA exonuclease activity	IDA	J:147868
Molecular Function	GO:0004540	RNA nuclease activity	ISO	J:164563
Molecular Function	GO:0035613	RNA stem-loop binding	IDA	J:228359
Molecular Function	GO:0035613	RNA stem-loop binding	IDA	J:229326
Molecular Function	GO:0035613	RNA stem-loop binding	IDA	J:228409
Cellular Component	GO:0005737	cytoplasm	IDA	J:147868
Cellular Component	GO:0005737	cytoplasm	IDA	J:229326
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:228359
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule	ISO	J:164563
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule	IBA	J:265628
Cellular Component	GO:0005856	cytoskeleton	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0042406	extrinsic component of endoplasmic reticulum membrane	IDA	J:228359
Cellular Component	GO:0042406	extrinsic component of endoplasmic reticulum membrane	IDA	J:229326
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:147868
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:228416
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0000932	P-body	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0005791	rough endoplasmic reticulum	IDA	J:228359
Cellular Component	GO:0005791	rough endoplasmic reticulum	IDA	J:229326
Biological Process	GO:0061158	3'-UTR-mediated mRNA destabilization	IDA	J:228409
Biological Process	GO:0061158	3'-UTR-mediated mRNA destabilization	IDA	J:229326
Biological Process	GO:0061158	3'-UTR-mediated mRNA destabilization	ISO	J:164563
Biological Process	GO:0061158	3'-UTR-mediated mRNA destabilization	IDA	J:228359
Biological Process	GO:0061158	3'-UTR-mediated mRNA destabilization	IDA	J:147868
Biological Process	GO:0061158	3'-UTR-mediated mRNA destabilization	IDA	J:228445
Biological Process	GO:0061158	3'-UTR-mediated mRNA destabilization	IBA	J:265628
Biological Process	GO:0001525	angiogenesis	IEA	J:60000
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:1990869	cellular response to chemokine	ISO	J:164563
Biological Process	GO:1990869	cellular response to chemokine	IDA	J:228414
Biological Process	GO:0042149	cellular response to glucose starvation	IDA	J:178149
Biological Process	GO:0071347	cellular response to interleukin-1	IDA	J:229326
Biological Process	GO:1904637	cellular response to ionomycin	IDA	J:228409
Biological Process	GO:0071222	cellular response to lipopolysaccharide	ISO	J:164563
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IDA	J:228359
Biological Process	GO:0071222	cellular response to lipopolysaccharide	ISS	J:196097
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IDA	J:174994
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IDA	J:229326
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IDA	J:147868
Biological Process	GO:0034599	cellular response to oxidative stress	IDA	J:178149
Biological Process	GO:1903936	cellular response to sodium arsenite	IDA	J:178149
Biological Process	GO:0071356	cellular response to tumor necrosis factor	ISO	J:164563
Biological Process	GO:0098586	cellular response to virus	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0002757	immune response-activating signaling pathway	ISO	J:164563
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0010587	miRNA catabolic process	ISO	J:164563
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0044828	negative regulation by host of viral genome replication	ISO	J:164563
Biological Process	GO:0055118	negative regulation of cardiac muscle contraction	IDA	J:174994
Biological Process	GO:1900016	negative regulation of cytokine production involved in inflammatory response	IDA	J:174994
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:196097
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	IDA	J:174994
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	IDA	J:174994
Biological Process	GO:0032715	negative regulation of interleukin-6 production	ISS	J:196097
Biological Process	GO:0032715	negative regulation of interleukin-6 production	IDA	J:174994
Biological Process	GO:0032715	negative regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0010656	negative regulation of muscle cell apoptotic process	IDA	J:174994
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	ISS	J:196097
Biological Process	GO:1901223	negative regulation of NIK/NF-kappaB signaling	IDA	J:174994
Biological Process	GO:0045019	negative regulation of nitric oxide biosynthetic process	ISO	J:164563
Biological Process	GO:0045019	negative regulation of nitric oxide biosynthetic process	IDA	J:174994
Biological Process	GO:0045019	negative regulation of nitric oxide biosynthetic process	ISS	J:196097
Biological Process	GO:0001933	negative regulation of protein phosphorylation	IDA	J:178149
Biological Process	GO:2000320	negative regulation of T-helper 17 cell differentiation	IMP	J:259145
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	IDA	J:174994
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	ISO	J:164563
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	ISS	J:196097
Biological Process	GO:0032689	negative regulation of type II interferon production	IDA	J:174994
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0000294	nuclear-transcribed mRNA catabolic process, RNase MRP-dependent	IDA	J:229326
Biological Process	GO:0000294	nuclear-transcribed mRNA catabolic process, RNase MRP-dependent	IBA	J:265628
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0010508	positive regulation of autophagy	IMP	J:196233
Biological Process	GO:0010508	positive regulation of autophagy	ISO	J:164563
Biological Process	GO:0010942	positive regulation of cell death	ISO	J:164563
Biological Process	GO:0002230	positive regulation of defense response to virus by host	ISO	J:164563
Biological Process	GO:0010595	positive regulation of endothelial cell migration	ISO	J:164563
Biological Process	GO:1900119	positive regulation of execution phase of apoptosis	IDA	J:178149
Biological Process	GO:0045600	positive regulation of fat cell differentiation	ISS	J:196233
Biological Process	GO:0045600	positive regulation of fat cell differentiation	IDA	J:228414
Biological Process	GO:0045600	positive regulation of fat cell differentiation	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISS	J:196233
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010884	positive regulation of lipid storage	ISO	J:164563
Biological Process	GO:0010884	positive regulation of lipid storage	IMP	J:196233
Biological Process	GO:2000627	positive regulation of miRNA catabolic process	ISO	J:164563
Biological Process	GO:0061014	positive regulation of mRNA catabolic process	ISO	J:164563
Biological Process	GO:0061014	positive regulation of mRNA catabolic process	IDA	J:228359
Biological Process	GO:0061014	positive regulation of mRNA catabolic process	IDA	J:147868
Biological Process	GO:0061014	positive regulation of mRNA catabolic process	IDA	J:229326
Biological Process	GO:0061014	positive regulation of mRNA catabolic process	IDA	J:228409
Biological Process	GO:1900745	positive regulation of p38MAPK cascade	ISO	J:164563
Biological Process	GO:1903003	positive regulation of protein deubiquitination	ISO	J:164563
Biological Process	GO:0042307	positive regulation of protein import into nucleus	ISO	J:164563
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	ISS	J:196233
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:228414
Biological Process	GO:0051259	protein complex oligomerization	ISO	J:164563
Biological Process	GO:0016579	protein deubiquitination	ISO	J:164563
Biological Process	GO:0010468	regulation of gene expression	ISO	J:164563
Biological Process	GO:0090501	RNA phosphodiester bond hydrolysis	IDA	J:147868
Biological Process	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	IDA	J:228359
Biological Process	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	IDA	J:229326
Biological Process	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	IBA	J:265628
Biological Process	GO:0050852	T cell receptor signaling pathway	IMP	J:259145
Biological Process	GO:0050852	T cell receptor signaling pathway	IDA	J:228409