GO Annotations Graph

• Symbol: Spg7
• Name: SPG7, paraplegin matrix AAA peptidase subunit
• ID: MGI:2385906

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0016887	ATP hydrolysis activity	IEA	J:72247
Molecular Function	GO:0004176	ATP-dependent peptidase activity	IEA	J:72247
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004222	metalloendopeptidase activity	IBA	J:265628
Molecular Function	GO:0008237	metallopeptidase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:164484
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0005745	m-AAA complex	IBA	J:265628
Cellular Component	GO:0005745	m-AAA complex	IDA	J:164484
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005743	mitochondrial inner membrane	IDA	J:164484
Cellular Component	GO:0005757	mitochondrial permeability transition pore complex	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IDA	J:164484
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	IDA	J:87616
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Biological Process	GO:0008089	anterograde axonal transport	IMP	J:87616
Biological Process	GO:0007155	cell adhesion	TAS	J:45282
Biological Process	GO:1902686	mitochondrial outer membrane permeabilization involved in programmed cell death	ISO	J:164563
Biological Process	GO:1902686	mitochondrial outer membrane permeabilization involved in programmed cell death	ISO	J:155856
Biological Process	GO:0034982	mitochondrial protein processing	IBA	J:265628
Biological Process	GO:0007005	mitochondrion organization	IMP	J:87616
Biological Process	GO:0006508	proteolysis	IEA	J:60000
Biological Process	GO:0006508	proteolysis	IEA	J:72247
Biological Process	GO:0030155	regulation of cell adhesion	TAS	J:45282
Biological Process	GO:0046902	regulation of mitochondrial membrane permeability	ISO	J:155856
Biological Process	GO:0046902	regulation of mitochondrial membrane permeability	ISO	J:164563