GO Annotations Graph

• Symbol: Eppk1
• Name: epiplakin 1
• ID: MGI:2386306

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019215	intermediate filament binding	ISO	J:164563
Molecular Function	GO:1990254	keratin filament binding	IPI	J:236209
Molecular Function	GO:1990254	keratin filament binding	IPI	J:138481
Molecular Function	GO:1990254	keratin filament binding	IBA	J:265628
Molecular Function	GO:0005198	structural molecule activity	IBA	J:265628
Cellular Component	GO:0016327	apicolateral plasma membrane	IDA	J:220637
Cellular Component	GO:0045178	basal part of cell	IDA	J:215291
Cellular Component	GO:0005923	bicellular tight junction	ISO	J:164563
Cellular Component	GO:0030054	cell junction	IBA	J:265628
Cellular Component	GO:0071944	cell periphery	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005911	cell-cell junction	IDA	J:215291
Cellular Component	GO:0005737	cytoplasm	IDA	J:237683
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:85100
Cellular Component	GO:0005856	cytoskeleton	IDA	J:236209
Cellular Component	GO:0005856	cytoskeleton	ISO	J:164563
Cellular Component	GO:0030056	hemidesmosome	ISO	J:164563
Cellular Component	GO:0045111	intermediate filament cytoskeleton	ISO	J:164563
Cellular Component	GO:0045095	keratin filament	ISO	J:164563
Cellular Component	GO:0045095	keratin filament	IDA	J:237683
Cellular Component	GO:0045095	keratin filament	IDA	J:138481
Cellular Component	GO:0045095	keratin filament	IBA	J:265628
Cellular Component	GO:0016020	membrane	IBA	J:265628
Cellular Component	GO:0097356	perinucleolar compartment	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Biological Process	GO:0007010	cytoskeleton organization	IMP	J:215291
Biological Process	GO:0045110	intermediate filament bundle assembly	IMP	J:237683
Biological Process	GO:0045110	intermediate filament bundle assembly	IBA	J:265628
Biological Process	GO:0045104	intermediate filament cytoskeleton organization	IEA	J:72247
Biological Process	GO:0045109	intermediate filament organization	ISO	J:164563
Biological Process	GO:0045109	intermediate filament organization	IDA	J:236209
Biological Process	GO:0045109	intermediate filament organization	IMP	J:138481
Biological Process	GO:0030336	negative regulation of cell migration	ISO	J:164563
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	ISO	J:164563
Biological Process	GO:0051548	negative regulation of keratinocyte migration	IMP	J:144147
Biological Process	GO:0010839	negative regulation of keratinocyte proliferation	IMP	J:144147
Biological Process	GO:0061045	negative regulation of wound healing	ISO	J:164563
Biological Process	GO:0061045	negative regulation of wound healing	IMP	J:237683
Biological Process	GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing	IMP	J:215291
Biological Process	GO:0030856	regulation of epithelial cell differentiation	IMP	J:215291
Biological Process	GO:1905041	regulation of epithelium regeneration	IMP	J:144147
Biological Process	GO:0042060	wound healing	ISO	J:164563
Biological Process	GO:0042060	wound healing	IBA	J:265628