GO Annotations Graph

• Symbol: Abca5
• Name: ATP-binding cassette, sub-family A member 5
• ID: MGI:2386607

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0140359	ABC-type transporter activity	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0042626	ATPase-coupled transmembrane transporter activity	IBA	J:265628
Molecular Function	GO:0005319	lipid transporter activity	IBA	J:265628
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0005794	Golgi apparatus	IBA	J:265628
Cellular Component	GO:0005770	late endosome	IDA	J:99152
Cellular Component	GO:0005770	late endosome	IBA	J:265628
Cellular Component	GO:0005764	lysosome	IDA	J:99152
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Biological Process	GO:0033344	cholesterol efflux	IMP	J:160341
Biological Process	GO:0042632	cholesterol homeostasis	ISO	J:164563
Biological Process	GO:0008203	cholesterol metabolic process	ISO	J:164563
Biological Process	GO:0030301	cholesterol transport	IEA	J:72247
Biological Process	GO:0034375	high-density lipoprotein particle remodeling	IMP	J:160341
Biological Process	GO:0006869	lipid transport	IBA	J:265628
Biological Process	GO:0010745	negative regulation of macrophage derived foam cell differentiation	IMP	J:160341
Biological Process	GO:1903064	positive regulation of reverse cholesterol transport	IMP	J:302471
Biological Process	GO:0010874	regulation of cholesterol efflux	ISO	J:164563
Biological Process	GO:0010874	regulation of cholesterol efflux	IMP	J:302471
Biological Process	GO:0043691	reverse cholesterol transport	IC	J:160341
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247