GO Annotations Graph

• Symbol: Tnip2
• Name: TNFAIP3 interacting protein 2
• ID: MGI:2386643

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	IEA	J:72247
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0031593	polyubiquitin modification-dependent protein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:157867
Molecular Function	GO:0005515	protein binding	IPI	J:76628
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:76628
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0023035	CD40 signaling pathway	IMP	J:112395
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IMP	J:112395
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IBA	J:265628
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IDA	J:76628
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	IMP	J:112395
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	ISO	J:164563
Biological Process	GO:0050871	positive regulation of B cell activation	IMP	J:112395
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IBA	J:265628
Biological Process	GO:0043032	positive regulation of macrophage activation	IMP	J:112395
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0050821	protein stabilization	IMP	J:112395
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0034134	toll-like receptor 2 signaling pathway	IMP	J:112395
Biological Process	GO:0034134	toll-like receptor 2 signaling pathway	IBA	J:265628
Biological Process	GO:0034138	toll-like receptor 3 signaling pathway	IMP	J:112395
Biological Process	GO:0034138	toll-like receptor 3 signaling pathway	IBA	J:265628
Biological Process	GO:0034162	toll-like receptor 9 signaling pathway	IMP	J:112395