GO Annotations Graph

• Symbol: Lnpep
• Name: leucyl/cystinyl aminopeptidase
• ID: MGI:2387123

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004177	aminopeptidase activity	ISO	J:155856
Molecular Function	GO:0004177	aminopeptidase activity	ISO	J:164563
Molecular Function	GO:0004177	aminopeptidase activity	IMP	J:76570
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0070006	metalloaminopeptidase activity	IBA	J:265628
Molecular Function	GO:0008237	metallopeptidase activity	IEA	J:72247
Molecular Function	GO:0008237	metallopeptidase activity	IEA	J:60000
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Molecular Function	GO:0042277	peptide binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:100750
Molecular Function	GO:0008270	zinc ion binding	IBA	J:265628
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:155856
Cellular Component	GO:0030659	cytoplasmic vesicle membrane	TAS	Reactome:R-MMU-1445145
Cellular Component	GO:0030659	cytoplasmic vesicle membrane	TAS	Reactome:R-MMU-1445150
Cellular Component	GO:0030659	cytoplasmic vesicle membrane	IDA	J:80816
Cellular Component	GO:0032593	insulin-responsive compartment	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0043229	intracellular organelle	ISO	J:155856
Cellular Component	GO:0016020	membrane	IMP	J:76570
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IDA	J:100750
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:100750
Cellular Component	GO:0031982	vesicle	ISO	J:155856
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	IMP	J:220356
Biological Process	GO:0010813	neuropeptide catabolic process	ISO	J:155856
Biological Process	GO:0043171	peptide catabolic process	ISO	J:155856
Biological Process	GO:0043171	peptide catabolic process	IBA	J:265628
Biological Process	GO:0045777	positive regulation of blood pressure	ISO	J:155856
Biological Process	GO:0030163	protein catabolic process	IMP	J:76570
Biological Process	GO:0006508	proteolysis	IBA	J:265628
Biological Process	GO:0008217	regulation of blood pressure	IBA	J:265628
Biological Process	GO:0048169	regulation of long-term neuronal synaptic plasticity	ISO	J:155856
Biological Process	GO:0009725	response to hormone	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IBA	J:265628
Biological Process	GO:0060395	SMAD protein signal transduction	IDA	J:195995