GO Annotations Graph

• Symbol: Cltc
• Name: clathrin heavy chain
• ID: MGI:2388633

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0030506	ankyrin binding	ISO	J:155856
Molecular Function	GO:0032051	clathrin light chain binding	ISO	J:164563
Molecular Function	GO:0032051	clathrin light chain binding	IBA	J:265628
Molecular Function	GO:0097718	disordered domain specific binding	ISO	J:164563
Molecular Function	GO:0003725	double-stranded RNA binding	ISO	J:170947
Molecular Function	GO:0031072	heat shock protein binding	ISO	J:155856
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	ISO	J:164563
Molecular Function	GO:0042277	peptide binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:248446
Molecular Function	GO:0005515	protein binding	IPI	J:227344
Molecular Function	GO:0005515	protein binding	IPI	J:214070
Molecular Function	GO:0005515	protein binding	IPI	J:215242
Molecular Function	GO:0019901	protein kinase binding	IPI	J:169453
Molecular Function	GO:0120283	protein serine/threonine kinase binding	ISO	J:155856
Molecular Function	GO:0005198	structural molecule activity	IEA	J:72247
Molecular Function	GO:1990381	ubiquitin-specific protease binding	ISO	J:164563
Cellular Component	GO:0030118	clathrin coat	ISO	J:164563
Cellular Component	GO:0030118	clathrin coat	ISO	J:155856
Cellular Component	GO:0030132	clathrin coat of coated pit	IEA	J:72247
Cellular Component	GO:0030130	clathrin coat of trans-Golgi network vesicle	IEA	J:72247
Cellular Component	GO:0071439	clathrin complex	ISO	J:164563
Cellular Component	GO:0071439	clathrin complex	IBA	J:265628
Cellular Component	GO:0045334	clathrin-coated endocytic vesicle	IBA	J:265628
Cellular Component	GO:0005905	clathrin-coated pit	IDA	J:227201
Cellular Component	GO:0030136	clathrin-coated vesicle	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005768	endosome	ISO	J:164563
Cellular Component	GO:0098850	extrinsic component of synaptic vesicle membrane	ISO	J:155856
Cellular Component	GO:0005764	lysosome	ISO	J:164563
Cellular Component	GO:0016020	membrane	IMP	J:156519
Cellular Component	GO:0030117	membrane coat	IDA	J:75306
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0072686	mitotic spindle	ISO	J:164563
Cellular Component	GO:1990498	mitotic spindle microtubule	ISO	J:164563
Cellular Component	GO:0031523	Myb complex	ISO	J:137631
Cellular Component	GO:0043209	myelin sheath	HDA	J:145263
Cellular Component	GO:0098684	photoreceptor ribbon synapse	IDA	J:199646
Cellular Component	GO:0098684	photoreceptor ribbon synapse	IDA	J:199646
Cellular Component	GO:0098684	photoreceptor ribbon synapse	IDA	J:199646
Cellular Component	GO:0098835	presynaptic endocytic zone membrane	IDA	J:199646
Cellular Component	GO:0098835	presynaptic endocytic zone membrane	IDA	J:199646
Cellular Component	GO:0098835	presynaptic endocytic zone membrane	IDA	J:199646
Cellular Component	GO:0032991	protein-containing complex	ISO	J:170947
Cellular Component	GO:0042383	sarcolemma	ISO	J:155856
Cellular Component	GO:0005819	spindle	ISO	J:164563
Cellular Component	GO:0005819	spindle	ISO	J:155856
Cellular Component	GO:0005819	spindle	IBA	J:265628
Cellular Component	GO:0030315	T-tubule	ISO	J:155856
Biological Process	GO:0150093	amyloid-beta clearance by transcytosis	ISO	J:164563
Biological Process	GO:0006914	autophagy	IEA	J:60000
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0051301	cell division	IEA	J:60000
Biological Process	GO:0048268	clathrin coat assembly	ISO	J:164563
Biological Process	GO:0048268	clathrin coat assembly	IBA	J:265628
Biological Process	GO:0072583	clathrin-dependent endocytosis	ISO	J:164563
Biological Process	GO:0007030	Golgi organization	ISO	J:155856
Biological Process	GO:0006886	intracellular protein transport	IEA	J:72247
Biological Process	GO:0000278	mitotic cell cycle	ISO	J:164563
Biological Process	GO:0000278	mitotic cell cycle	ISO	J:155856
Biological Process	GO:0000278	mitotic cell cycle	IBA	J:265628
Biological Process	GO:0090307	mitotic spindle assembly	ISO	J:137631
Biological Process	GO:1900126	negative regulation of hyaluronan biosynthetic process	ISO	J:164563
Biological Process	GO:1903077	negative regulation of protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0031623	receptor internalization	ISO	J:164563
Biological Process	GO:0006898	receptor-mediated endocytosis	ISO	J:164563
Biological Process	GO:0006898	receptor-mediated endocytosis	ISO	J:155856
Biological Process	GO:0006898	receptor-mediated endocytosis	IBA	J:265628
Biological Process	GO:0060236	regulation of mitotic spindle organization	ISO	J:164563
Biological Process	GO:0042147	retrograde transport, endosome to Golgi	ISO	J:164563
Biological Process	GO:0048488	synaptic vesicle endocytosis	ISO	J:155856
Biological Process	GO:0033572	transferrin transport	ISO	J:164563
Biological Process	GO:0016192	vesicle-mediated transport	IEA	J:72247