GO Annotations Graph

• Symbol: Brcc3
• Name: BRCA1/BRCA2-containing complex, subunit 3
• ID: MGI:2389572

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004843	cysteine-type deubiquitinase activity	IEA	J:72247
Molecular Function	GO:0030234	enzyme regulator activity	ISO	J:73065
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0061578	K63-linked deubiquitinase activity	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0140492	metal-dependent deubiquitinase activity	IDA	J:331359
Molecular Function	GO:0140492	metal-dependent deubiquitinase activity	ISO	J:164563
Molecular Function	GO:0008237	metallopeptidase activity	ISO	J:164563
Molecular Function	GO:0008237	metallopeptidase activity	IBA	J:265628
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Molecular Function	GO:0031593	polyubiquitin modification-dependent protein binding	ISO	J:164563
Molecular Function	GO:0031593	polyubiquitin modification-dependent protein binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:319940
Molecular Function	GO:0005515	protein binding	IPI	J:199404
Molecular Function	GO:0005515	protein binding	IPI	J:193213
Cellular Component	GO:0070531	BRCA1-A complex	NAS	J:320081
Cellular Component	GO:0070531	BRCA1-A complex	ISO	J:164563
Cellular Component	GO:0070531	BRCA1-A complex	IBA	J:265628
Cellular Component	GO:0070552	BRISC complex	ISO	J:164563
Cellular Component	GO:0070552	BRISC complex	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0000152	nuclear ubiquitin ligase complex	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	NAS	J:320081
Cellular Component	GO:0000151	ubiquitin ligase complex	ISO	J:73065
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0051301	cell division	IEA	J:60000
Biological Process	GO:0071479	cellular response to ionizing radiation	ISO	J:164563
Biological Process	GO:0006325	chromatin organization	IEA	J:60000
Biological Process	GO:0006974	DNA damage response	IEA	J:60000
Biological Process	GO:0006281	DNA repair	IEA	J:72247
Biological Process	GO:0006281	DNA repair	IEA	J:60000
Biological Process	GO:0006302	double-strand break repair	ISO	J:164563
Biological Process	GO:0006302	double-strand break repair	IBA	J:265628
Biological Process	GO:0070537	histone H2A K63-linked deubiquitination	ISO	J:164563
Biological Process	GO:0070537	histone H2A K63-linked deubiquitination	NAS	J:320081
Biological Process	GO:0070537	histone H2A K63-linked deubiquitination	IBA	J:265628
Biological Process	GO:0035518	histone H2A monoubiquitination	NAS	J:320082
Biological Process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	ISO	J:164563
Biological Process	GO:0044818	mitotic G2/M transition checkpoint	NAS	J:320080
Biological Process	GO:0045739	positive regulation of DNA repair	ISO	J:164563
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	ISO	J:164563
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	IDA	J:331359
Biological Process	GO:0051865	protein autoubiquitination	NAS	J:320082
Biological Process	GO:0016579	protein deubiquitination	IDA	J:319940
Biological Process	GO:0070536	protein K63-linked deubiquitination	IDA	J:331359
Biological Process	GO:0070536	protein K63-linked deubiquitination	ISO	J:164563
Biological Process	GO:0006508	proteolysis	IEA	J:60000
Biological Process	GO:2000001	regulation of DNA damage checkpoint	NAS	J:320084
Biological Process	GO:0006282	regulation of DNA repair	NAS	J:320081
Biological Process	GO:0010212	response to ionizing radiation	ISO	J:164563
Biological Process	GO:0010165	response to X-ray	ISO	J:73065