GO Annotations Graph

• Symbol: Nod2
• Name: nucleotide-binding oligomerization domain containing 2
• ID: MGI:2429397

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0050700	CARD domain binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0030544	Hsp70 protein binding	ISO	J:164563
Molecular Function	GO:0051879	Hsp90 protein binding	ISO	J:164563
Molecular Function	GO:0032500	muramyl dipeptide binding	ISO	J:164563
Molecular Function	GO:0032500	muramyl dipeptide binding	ISO	J:155856
Molecular Function	GO:0032500	muramyl dipeptide binding	IDA	J:132395
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0038187	pattern recognition receptor activity	ISO	J:164563
Molecular Function	GO:0042834	peptidoglycan binding	TAS	J:114723
Molecular Function	GO:0042834	peptidoglycan binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:169881
Molecular Function	GO:0005515	protein binding	IPI	J:161279
Molecular Function	GO:0005515	protein binding	IPI	J:117799
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0030296	protein tyrosine kinase activator activity	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Molecular Function	GO:0030546	signaling receptor activator activity	ISO	J:164563
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	TAS	J:114723
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005856	cytoskeleton	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-741383
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045335	phagocytic vesicle	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0031982	vesicle	ISO	J:164563
Biological Process	GO:0002253	activation of immune response	IMP	J:96035
Biological Process	GO:0002815	biosynthetic process of antibacterial peptides active against Gram-positive bacteria	IMP	J:96035
Biological Process	GO:0071222	cellular response to lipopolysaccharide	ISO	J:164563
Biological Process	GO:0071225	cellular response to muramyl dipeptide	ISO	J:164563
Biological Process	GO:0071224	cellular response to peptidoglycan	IMP	J:113450
Biological Process	GO:0006952	defense response	TAS	J:114723
Biological Process	GO:0042742	defense response to bacterium	ISO	J:164563
Biological Process	GO:0042742	defense response to bacterium	IBA	J:265628
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IMP	J:96035
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IMP	J:132126
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IMP	J:147177
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IMP	J:147177
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IGI	J:132126
Biological Process	GO:0016045	detection of bacterium	ISO	J:164563
Biological Process	GO:0009595	detection of biotic stimulus	TAS	J:114723
Biological Process	GO:0032498	detection of muramyl dipeptide	ISO	J:73065
Biological Process	GO:0070371	ERK1 and ERK2 cascade	IDA	J:132126
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:147177
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IDA	J:132126
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0002381	immunoglobulin production involved in immunoglobulin-mediated immune response	IMP	J:96035
Biological Process	GO:0006954	inflammatory response	TAS	J:114723
Biological Process	GO:0045087	innate immune response	ISO	J:164563
Biological Process	GO:0002227	innate immune response in mucosa	IMP	J:96035
Biological Process	GO:0032615	interleukin-12 production	IMP	J:86264
Biological Process	GO:0032615	interleukin-12 production	IMP	J:91804
Biological Process	GO:0032615	interleukin-12 production	IMP	J:96035
Biological Process	GO:0032615	interleukin-12 production	IDA	J:91804
Biological Process	GO:0032621	interleukin-18 production	IMP	J:91804
Biological Process	GO:0032623	interleukin-2 production	IMP	J:147177
Biological Process	GO:0032635	interleukin-6 production	IMP	J:96035
Biological Process	GO:0032635	interleukin-6 production	IMP	J:132126
Biological Process	GO:0032635	interleukin-6 production	IDA	J:132126
Biological Process	GO:0032635	interleukin-6 production	IGI	J:132126
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:164563
Biological Process	GO:0007254	JNK cascade	IDA	J:132126
Biological Process	GO:0010934	macrophage cytokine production	IGI	J:132126
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:91804
Biological Process	GO:0010934	macrophage cytokine production	IDA	J:91804
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:96035
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:86264
Biological Process	GO:0010934	macrophage cytokine production	IDA	J:132126
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:132126
Biological Process	GO:0071608	macrophage inflammatory protein-1 alpha production	IMP	J:147177
Biological Process	GO:0030277	maintenance of gastrointestinal epithelium	ISO	J:164563
Biological Process	GO:0000165	MAPK cascade	IMP	J:96035
Biological Process	GO:0002862	negative regulation of inflammatory response to antigenic stimulus	IMP	J:113450
Biological Process	GO:0032695	negative regulation of interleukin-12 production	IDA	J:91804
Biological Process	GO:0032695	negative regulation of interleukin-12 production	IMP	J:113450
Biological Process	GO:0032695	negative regulation of interleukin-12 production	IMP	J:91804
Biological Process	GO:0032701	negative regulation of interleukin-18 production	IMP	J:91804
Biological Process	GO:0032703	negative regulation of interleukin-2 production	IMP	J:147177
Biological Process	GO:2000110	negative regulation of macrophage apoptotic process	IDA	J:170396
Biological Process	GO:0010936	negative regulation of macrophage cytokine production	IMP	J:91804
Biological Process	GO:0010936	negative regulation of macrophage cytokine production	IMP	J:91804
Biological Process	GO:0010936	negative regulation of macrophage cytokine production	IMP	J:91804
Biological Process	GO:0010936	negative regulation of macrophage cytokine production	IDA	J:91804
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	IMP	J:91804
Biological Process	GO:0002710	negative regulation of T cell mediated immunity	IMP	J:113450
Biological Process	GO:0034136	negative regulation of toll-like receptor 2 signaling pathway	IMP	J:91804
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	IMP	J:147177
Biological Process	GO:0032689	negative regulation of type II interferon production	IMP	J:91804
Biological Process	GO:0032689	negative regulation of type II interferon production	IMP	J:147177
Biological Process	GO:0038061	NIK/NF-kappaB signaling	IMP	J:178691
Biological Process	GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	IMP	J:208236
Biological Process	GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	ISO	J:73065
Biological Process	GO:0002221	pattern recognition receptor signaling pathway	ISO	J:164563
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IMP	J:96035
Biological Process	GO:0006909	phagocytosis	IMP	J:147177
Biological Process	GO:0006963	positive regulation of antibacterial peptide biosynthetic process	IDA	J:132395
Biological Process	GO:0050871	positive regulation of B cell activation	ISO	J:164563
Biological Process	GO:0006965	positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria	IMP	J:96035
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0002720	positive regulation of cytokine production involved in immune response	ISO	J:164563
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	ISO	J:164563
Biological Process	GO:0002606	positive regulation of dendritic cell antigen processing and presentation	IMP	J:159410
Biological Process	GO:0002732	positive regulation of dendritic cell cytokine production	ISO	J:155856
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	IMP	J:169873
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA	J:170396
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IMP	J:178691
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA	J:132126
Biological Process	GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin	IMP	J:96035
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IBA	J:265628
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:73065
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IDA	J:132126
Biological Process	GO:0045089	positive regulation of innate immune response	IDA	J:170396
Biological Process	GO:0045089	positive regulation of innate immune response	IMP	J:96035
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	ISO	J:164563
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IDA	J:169881
Biological Process	GO:0032733	positive regulation of interleukin-10 production	IMP	J:170396
Biological Process	GO:0032735	positive regulation of interleukin-12 production	IDA	J:91804
Biological Process	GO:0032735	positive regulation of interleukin-12 production	IMP	J:96035
Biological Process	GO:0032735	positive regulation of interleukin-12 production	IMP	J:91804
Biological Process	GO:0032735	positive regulation of interleukin-12 production	IMP	J:86264
Biological Process	GO:0032740	positive regulation of interleukin-17 production	ISO	J:164563
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:132126
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IDA	J:132126
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:96035
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IGI	J:132126
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:0046330	positive regulation of JNK cascade	ISO	J:117799
Biological Process	GO:0046330	positive regulation of JNK cascade	IDA	J:132126
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IC	J:132126
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:96035
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IGI	J:132126
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:96035
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:91804
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:86264
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IDA	J:132126
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IDA	J:91804
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IDA	J:132126
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:132126
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:132126
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IGI	J:132126
Biological Process	GO:0043406	positive regulation of MAP kinase activity	IDA	J:170396
Biological Process	GO:0043410	positive regulation of MAPK cascade	IMP	J:96035
Biological Process	GO:0071639	positive regulation of monocyte chemotactic protein-1 production	IMP	J:221560
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IMP	J:91804
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:73065
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	IMP	J:178691
Biological Process	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	IMP	J:170396
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	IDA	J:170396
Biological Process	GO:0051353	positive regulation of oxidoreductase activity	IDA	J:170396
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IMP	J:96035
Biological Process	GO:0050766	positive regulation of phagocytosis	IMP	J:147177
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	IMP	J:170396
Biological Process	GO:2000363	positive regulation of prostaglandin-E synthase activity	IDA	J:170396
Biological Process	GO:0060585	positive regulation of prostaglandin-endoperoxide synthase activity	IDA	J:170396
Biological Process	GO:1902523	positive regulation of protein K63-linked ubiquitination	ISO	J:164563
Biological Process	GO:0031398	positive regulation of protein ubiquitination	IDA	J:159062
Biological Process	GO:0032874	positive regulation of stress-activated MAPK cascade	IDA	J:132126
Biological Process	GO:0032874	positive regulation of stress-activated MAPK cascade	ISO	J:117799
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:164563
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IGI	J:132126
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:132126
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IDA	J:132126
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:91804
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:117799
Biological Process	GO:0002830	positive regulation of type 2 immune response	ISO	J:164563
Biological Process	GO:1904417	positive regulation of xenophagy	IMP	J:178691
Biological Process	GO:1904417	positive regulation of xenophagy	IMP	J:178691
Biological Process	GO:0042981	regulation of apoptotic process	IEA	J:72247
Biological Process	GO:0050727	regulation of inflammatory response	IMP	J:178054
Biological Process	GO:0090022	regulation of neutrophil chemotaxis	IMP	J:147177
Biological Process	GO:0043330	response to exogenous dsRNA	IMP	J:96035
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:96035
Biological Process	GO:0032496	response to lipopolysaccharide	IMP	J:86264
Biological Process	GO:0032495	response to muramyl dipeptide	ISO	J:164563
Biological Process	GO:0032495	response to muramyl dipeptide	ISO	J:155856
Biological Process	GO:0032495	response to muramyl dipeptide	IDA	J:169881
Biological Process	GO:0032495	response to muramyl dipeptide	IBA	J:265628
Biological Process	GO:0032495	response to muramyl dipeptide	IMP	J:91804
Biological Process	GO:0032495	response to muramyl dipeptide	IDA	J:91804
Biological Process	GO:0032495	response to muramyl dipeptide	IMP	J:96035
Biological Process	GO:0032495	response to muramyl dipeptide	IMP	J:86264
Biological Process	GO:0032494	response to peptidoglycan	IDA	J:91804
Biological Process	GO:0032494	response to peptidoglycan	IMP	J:91804
Biological Process	GO:0007165	signal transduction	TAS	J:114723
Biological Process	GO:0051403	stress-activated MAPK cascade	IDA	J:132126
Biological Process	GO:0034134	toll-like receptor 2 signaling pathway	IMP	J:91804
Biological Process	GO:0032640	tumor necrosis factor production	IGI	J:132126
Biological Process	GO:0032640	tumor necrosis factor production	IMP	J:132126
Biological Process	GO:0032640	tumor necrosis factor production	IDA	J:132126
Biological Process	GO:0032640	tumor necrosis factor production	IMP	J:147177
Biological Process	GO:0032609	type II interferon production	IMP	J:147177
Biological Process	GO:0032609	type II interferon production	IMP	J:91804
Biological Process	GO:0098792	xenophagy	IMP	J:178691
Biological Process	GO:0098792	xenophagy	IMP	J:178691