GO Annotations Graph

• Symbol: Adam1a
• Name: a disintegrin and metallopeptidase domain 1a
• ID: MGI:2429504

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004222	metalloendopeptidase activity	IBA	J:265628
Molecular Function	GO:0008237	metallopeptidase activity	NAS	J:77933
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:92271
Cellular Component	GO:0009897	external side of plasma membrane	IBA	J:265628
Cellular Component	GO:0016020	membrane	NAS	J:77933
Cellular Component	GO:0045121	membrane raft	IDA	J:92271
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:1990913	sperm head plasma membrane	IBA	J:265628
Biological Process	GO:0007339	binding of sperm to zona pellucida	IBA	J:265628
Biological Process	GO:0007339	binding of sperm to zona pellucida	IMP	J:92271
Biological Process	GO:0007342	fusion of sperm to egg plasma membrane involved in single fertilization	NAS	J:30468
Biological Process	GO:0008584	male gonad development	IBA	J:265628
Biological Process	GO:0006508	proteolysis	NAS	J:77933
Biological Process	GO:0006508	proteolysis	IBA	J:265628