GO Annotations Graph

• Symbol: Irak2
• Name: interleukin-1 receptor-associated kinase 2
• ID: MGI:2429603

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:71392
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	ISO	J:79614
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IEA	J:72247
Biological Process	GO:0006954	inflammatory response	IEA	J:72247
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IDA	J:91272
Biological Process	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	IEA	J:72247
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	IDA	J:91272
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IBA	J:265628
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IDA	J:91272
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0042981	regulation of apoptotic process	RCA	J:84168
Biological Process	GO:0001959	regulation of cytokine-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0070555	response to interleukin-1	ISO	J:164563
Biological Process	GO:0007165	signal transduction	IEA	J:72247