GO Annotations Graph

• Symbol: Rapgef3
• Name: Rap guanine nucleotide exchange factor (GEF) 3
• ID: MGI:2441741

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0030552	cAMP binding	ISO	J:155856
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ISO	J:164563
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IBA	J:265628
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IDA	J:88364
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:197247
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:164563
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:155856
Cellular Component	GO:0045177	apical part of cell	ISO	J:155856
Cellular Component	GO:0043679	axon terminus	ISO	J:155856
Cellular Component	GO:0009925	basal plasma membrane	ISO	J:155856
Cellular Component	GO:1990794	basolateral part of cell	ISO	J:155856
Cellular Component	GO:0031526	brush border membrane	ISO	J:155856
Cellular Component	GO:0071944	cell periphery	ISO	J:155856
Cellular Component	GO:0030864	cortical actin cytoskeleton	ISO	J:164563
Cellular Component	GO:0030864	cortical actin cytoskeleton	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0030175	filopodium	ISO	J:164563
Cellular Component	GO:0030175	filopodium	ISO	J:155856
Cellular Component	GO:0030426	growth cone	ISO	J:155856
Cellular Component	GO:0030027	lamellipodium	ISO	J:155856
Cellular Component	GO:0030027	lamellipodium	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005902	microvillus	ISO	J:164563
Cellular Component	GO:0005902	microvillus	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0031090	organelle membrane	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:1990796	photoreceptor cell terminal bouton	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0097470	ribbon synapse	ISO	J:155856
Cellular Component	GO:1990795	rod bipolar cell terminal bouton	ISO	J:155856
Biological Process	GO:0001525	angiogenesis	IEA	J:60000
Biological Process	GO:0008306	associative learning	IMP	J:225991
Biological Process	GO:0071320	cellular response to cAMP	ISO	J:164563
Biological Process	GO:0061028	establishment of endothelial barrier	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	IEA	J:72247
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	ISO	J:155856
Biological Process	GO:0032966	negative regulation of collagen biosynthetic process	ISO	J:155856
Biological Process	GO:0034242	negative regulation of syncytium formation by plasma membrane fusion	ISO	J:164563
Biological Process	GO:2000251	positive regulation of actin cytoskeleton reorganization	ISO	J:155856
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:164563
Biological Process	GO:1904427	positive regulation of calcium ion transmembrane transport	ISO	J:155856
Biological Process	GO:0045793	positive regulation of cell size	ISO	J:155856
Biological Process	GO:1904426	positive regulation of GTP binding	ISO	J:155856
Biological Process	GO:0043547	positive regulation of GTPase activity	ISO	J:164563
Biological Process	GO:0043547	positive regulation of GTPase activity	IBA	J:265628
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:1904453	positive regulation of potassium:proton exchanging ATPase activity	ISO	J:155856
Biological Process	GO:1901985	positive regulation of protein acetylation	ISO	J:164563
Biological Process	GO:0046827	positive regulation of protein export from nucleus	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	ISO	J:155856
Biological Process	GO:0051496	positive regulation of stress fiber assembly	ISO	J:164563
Biological Process	GO:0060143	positive regulation of syncytium formation by plasma membrane fusion	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0032486	Rap protein signal transduction	ISO	J:164563
Biological Process	GO:0007265	Ras protein signal transduction	IBA	J:265628
Biological Process	GO:2000249	regulation of actin cytoskeleton reorganization	ISO	J:164563
Biological Process	GO:0045765	regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0014066	regulation of phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0007264	small GTPase mediated signal transduction	IEA	J:72247