GO Annotations Graph

• Symbol: Mfn2
• Name: mitofusin 2
• ID: MGI:2442230

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005525	GTP binding	ISO	J:155856
Molecular Function	GO:0003924	GTPase activity	IBA	J:265628
Molecular Function	GO:0051020	GTPase binding	ISO	J:155856
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:122960
Molecular Function	GO:0005515	protein binding	IPI	J:164708
Molecular Function	GO:0005515	protein binding	IPI	J:200066
Molecular Function	GO:0005515	protein binding	IPI	J:211366
Molecular Function	GO:0005515	protein binding	IPI	J:186336
Molecular Function	GO:0005515	protein binding	IPI	J:81438
Molecular Function	GO:0005515	protein binding	IPI	J:81438
Molecular Function	GO:0005515	protein binding	IPI	J:186336
Molecular Function	GO:0043394	proteoglycan binding	ISO	J:155856
Molecular Function	GO:0031267	small GTPase binding	ISO	J:155856
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0015630	microtubule cytoskeleton	IDA	J:100252
Cellular Component	GO:0015630	microtubule cytoskeleton	IDA	J:100252
Cellular Component	GO:0015630	microtubule cytoskeleton	IDA	J:100252
Cellular Component	GO:0015630	microtubule cytoskeleton	IDA	J:100252
Cellular Component	GO:0015630	microtubule cytoskeleton	IDA	J:100252
Cellular Component	GO:0015630	microtubule cytoskeleton	IDA	J:100252
Cellular Component	GO:0005741	mitochondrial outer membrane	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IDA	J:186336
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	IDA	J:113296
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0006914	autophagy	IEA	J:60000
Biological Process	GO:0001825	blastocyst formation	IMP	J:100252
Biological Process	GO:0048593	camera-type eye morphogenesis	IMP	J:100636
Biological Process	GO:0048312	intracellular distribution of mitochondria	ISO	J:155856
Biological Process	GO:0051560	mitochondrial calcium ion homeostasis	ISO	J:155856
Biological Process	GO:0008053	mitochondrial fusion	IMP	J:281198
Biological Process	GO:0008053	mitochondrial fusion	ISO	J:155856
Biological Process	GO:0008053	mitochondrial fusion	IMP	J:211366
Biological Process	GO:0008053	mitochondrial fusion	ISO	J:164563
Biological Process	GO:0008053	mitochondrial fusion	IGI	J:281198
Biological Process	GO:0008053	mitochondrial fusion	IBA	J:265628
Biological Process	GO:0008053	mitochondrial fusion	IMP	J:81438
Biological Process	GO:0008053	mitochondrial fusion	IMP	J:183839
Biological Process	GO:0007006	mitochondrial membrane organization	ISO	J:164563
Biological Process	GO:0051646	mitochondrion localization	ISO	J:164563
Biological Process	GO:0051646	mitochondrion localization	IBA	J:265628
Biological Process	GO:0070584	mitochondrion morphogenesis	ISO	J:155856
Biological Process	GO:0007005	mitochondrion organization	ISO	J:155856
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	ISO	J:155856
Biological Process	GO:0045786	negative regulation of cell cycle	ISO	J:155856
Biological Process	GO:0060548	negative regulation of cell death	ISO	J:155856
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0045792	negative regulation of cell size	ISO	J:155856
Biological Process	GO:0060253	negative regulation of glial cell proliferation	ISO	J:155856
Biological Process	GO:0090258	negative regulation of mitochondrial fission	ISO	J:155856
Biological Process	GO:1901215	negative regulation of neuron death	ISO	J:155856
Biological Process	GO:0046580	negative regulation of Ras protein signal transduction	ISO	J:164563
Biological Process	GO:1903427	negative regulation of reactive oxygen species biosynthetic process	ISO	J:155856
Biological Process	GO:0090201	negative regulation of release of cytochrome c from mitochondria	ISO	J:155856
Biological Process	GO:0060299	negative regulation of sarcomere organization	ISO	J:155856
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0061734	parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization	IMP	J:198571
Biological Process	GO:1901857	positive regulation of cellular respiration	ISO	J:155856
Biological Process	GO:0035563	positive regulation of chromatin binding	ISO	J:155856
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:243572
Biological Process	GO:0061003	positive regulation of dendritic spine morphogenesis	ISO	J:155856
Biological Process	GO:2000866	positive regulation of estradiol secretion	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0046326	positive regulation of glucose import	ISO	J:155856
Biological Process	GO:0010729	positive regulation of hydrogen peroxide biosynthetic process	ISO	J:155856
Biological Process	GO:0046628	positive regulation of insulin receptor signaling pathway	ISO	J:155856
Biological Process	GO:0010918	positive regulation of mitochondrial membrane potential	ISO	J:155856
Biological Process	GO:2000386	positive regulation of ovarian follicle development	ISO	J:155856
Biological Process	GO:2000872	positive regulation of progesterone secretion	ISO	J:155856
Biological Process	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	ISO	J:155856
Biological Process	GO:1905461	positive regulation of vascular associated smooth muscle cell apoptotic process	ISO	J:164563
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0034497	protein localization to phagophore assembly site	ISO	J:73065
Biological Process	GO:0006626	protein targeting to mitochondrion	ISO	J:164563
Biological Process	GO:0006986	response to unfolded protein	IEA	J:60000