GO Annotations Graph

• Symbol: Cgas
• Name: cyclic GMP-AMP synthase
• ID: MGI:2442261

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0061501	2',3'-cyclic GMP-AMP synthase activity	IDA	J:314373
Molecular Function	GO:0061501	2',3'-cyclic GMP-AMP synthase activity	ISO	J:164563
Molecular Function	GO:0061501	2',3'-cyclic GMP-AMP synthase activity	IDA	J:268008
Molecular Function	GO:0061501	2',3'-cyclic GMP-AMP synthase activity	IDA	J:314911
Molecular Function	GO:0061501	2',3'-cyclic GMP-AMP synthase activity	IDA	J:243562
Molecular Function	GO:0061501	2',3'-cyclic GMP-AMP synthase activity	IDA	J:257953
Molecular Function	GO:0061501	2',3'-cyclic GMP-AMP synthase activity	IDA	J:243386
Molecular Function	GO:0061501	2',3'-cyclic GMP-AMP synthase activity	IDA	J:241014
Molecular Function	GO:0061501	2',3'-cyclic GMP-AMP synthase activity	IDA	J:231311
Molecular Function	GO:0061501	2',3'-cyclic GMP-AMP synthase activity	IDA	J:281254
Molecular Function	GO:0061501	2',3'-cyclic GMP-AMP synthase activity	IDA	J:313955
Molecular Function	GO:0061501	2',3'-cyclic GMP-AMP synthase activity	IMP	J:196208
Molecular Function	GO:0061501	2',3'-cyclic GMP-AMP synthase activity	IBA	J:265628
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0003682	chromatin binding	ISO	J:164563
Molecular Function	GO:0003682	chromatin binding	IDA	J:313955
Molecular Function	GO:0003682	chromatin binding	IDA	J:243562
Molecular Function	GO:0003682	chromatin binding	IDA	J:314373
Molecular Function	GO:0003682	chromatin binding	IDA	J:314911
Molecular Function	GO:0003682	chromatin binding	IDA	J:243563
Molecular Function	GO:0003682	chromatin binding	IBA	J:265628
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IDA	J:231311
Molecular Function	GO:0003690	double-stranded DNA binding	IDA	J:241001
Molecular Function	GO:0003690	double-stranded DNA binding	IDA	J:268008
Molecular Function	GO:0003690	double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0003690	double-stranded DNA binding	IDA	J:313955
Molecular Function	GO:0003690	double-stranded DNA binding	IDA	J:314911
Molecular Function	GO:0003690	double-stranded DNA binding	IDA	J:241014
Molecular Function	GO:0003690	double-stranded DNA binding	IDA	J:314373
Molecular Function	GO:0003690	double-stranded DNA binding	IDA	J:243386
Molecular Function	GO:0003690	double-stranded DNA binding	IBA	J:265628
Molecular Function	GO:0008047	enzyme activator activity	ISO	J:164563
Molecular Function	GO:0005525	GTP binding	IEA	J:60000
Molecular Function	GO:0008289	lipid binding	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0140693	molecular condensate scaffold activity	ISO	J:164563
Molecular Function	GO:0140677	molecular function activator activity	ISO	J:164563
Molecular Function	GO:0140678	molecular function inhibitor activity	ISO	J:164563
Molecular Function	GO:0031491	nucleosome binding	IDA	J:314911
Molecular Function	GO:0031491	nucleosome binding	IDA	J:313955
Molecular Function	GO:0031491	nucleosome binding	IDA	J:314373
Molecular Function	GO:0031491	nucleosome binding	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0016779	nucleotidyltransferase activity	IEA	J:60000
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	ISO	J:164563
Molecular Function	GO:0160004	poly-ADP-D-ribose modification-dependent protein binding	IDA	J:326061
Molecular Function	GO:0005515	protein binding	IPI	J:231311
Molecular Function	GO:0005515	protein binding	IPI	J:267189
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	IDA	J:257953
Molecular Function	GO:0042803	protein homodimerization activity	IDA	J:314373
Molecular Function	GO:0042803	protein homodimerization activity	IDA	J:314911
Molecular Function	GO:0042803	protein homodimerization activity	IDA	J:313955
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IDA	J:273551
Cellular Component	GO:0005829	cytosol	IDA	J:196208
Cellular Component	GO:0005829	cytosol	IDA	J:280913
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016604	nuclear body	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:280913
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:326061
Cellular Component	GO:0005886	plasma membrane	IDA	J:273551
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0035861	site of double-strand break	ISO	J:164563
Cellular Component	GO:0035861	site of double-strand break	IBA	J:265628
Biological Process	GO:0002218	activation of innate immune response	ISO	J:164563
Biological Process	GO:0002218	activation of innate immune response	IDA	J:199863
Biological Process	GO:0002218	activation of innate immune response	IDA	J:257953
Biological Process	GO:0002218	activation of innate immune response	IDA	J:314911
Biological Process	GO:0002218	activation of innate immune response	IMP	J:196208
Biological Process	GO:0002218	activation of innate immune response	IDA	J:243386
Biological Process	GO:0002218	activation of innate immune response	IDA	J:313955
Biological Process	GO:0002218	activation of innate immune response	IDA	J:314373
Biological Process	GO:0002218	activation of innate immune response	IBA	J:265628
Biological Process	GO:0019933	cAMP-mediated signaling	IMP	J:196208
Biological Process	GO:0019933	cAMP-mediated signaling	IDA	J:243386
Biological Process	GO:0019933	cAMP-mediated signaling	IDA	J:243562
Biological Process	GO:0019933	cAMP-mediated signaling	IDA	J:268008
Biological Process	GO:0019933	cAMP-mediated signaling	ISO	J:164563
Biological Process	GO:0071360	cellular response to exogenous dsRNA	IMP	J:196208
Biological Process	GO:0071360	cellular response to exogenous dsRNA	IDA	J:241014
Biological Process	GO:0071360	cellular response to exogenous dsRNA	IDA	J:241001
Biological Process	GO:0071360	cellular response to exogenous dsRNA	IDA	J:243386
Biological Process	GO:0071360	cellular response to exogenous dsRNA	IBA	J:265628
Biological Process	GO:0019934	cGMP-mediated signaling	IMP	J:196208
Biological Process	GO:0019934	cGMP-mediated signaling	IDA	J:243386
Biological Process	GO:0019934	cGMP-mediated signaling	IDA	J:243562
Biological Process	GO:0019934	cGMP-mediated signaling	ISO	J:164563
Biological Process	GO:0002753	cytosolic pattern recognition receptor signaling pathway	ISO	J:164563
Biological Process	GO:0051607	defense response to virus	IDA	J:243386
Biological Process	GO:0051607	defense response to virus	IDA	J:199863
Biological Process	GO:0051607	defense response to virus	ISO	J:164563
Biological Process	GO:0008340	determination of adult lifespan	IGI	J:226998
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	IBA	J:265628
Biological Process	GO:0006281	DNA repair	IEA	J:60000
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0045087	innate immune response	ISO	J:164563
Biological Process	GO:0045738	negative regulation of DNA repair	IDA	J:326061
Biological Process	GO:2000042	negative regulation of double-strand break repair via homologous recombination	IDA	J:280913
Biological Process	GO:2000042	negative regulation of double-strand break repair via homologous recombination	ISO	J:164563
Biological Process	GO:2000042	negative regulation of double-strand break repair via homologous recombination	IMP	J:267189
Biological Process	GO:2000042	negative regulation of double-strand break repair via homologous recombination	IBA	J:265628
Biological Process	GO:0045824	negative regulation of innate immune response	ISO	J:164563
Biological Process	GO:0038001	paracrine signaling	IDA	J:243386
Biological Process	GO:0038001	paracrine signaling	IDA	J:243563
Biological Process	GO:0038001	paracrine signaling	ISO	J:164563
Biological Process	GO:0038001	paracrine signaling	IBA	J:265628
Biological Process	GO:0002221	pattern recognition receptor signaling pathway	ISO	J:164563
Biological Process	GO:2000774	positive regulation of cellular senescence	IDA	J:243563
Biological Process	GO:0002230	positive regulation of defense response to virus by host	IDA	J:243386
Biological Process	GO:0002230	positive regulation of defense response to virus by host	IMP	J:196208
Biological Process	GO:0002230	positive regulation of defense response to virus by host	ISO	J:164563
Biological Process	GO:0002230	positive regulation of defense response to virus by host	IDA	J:199863
Biological Process	GO:0002230	positive regulation of defense response to virus by host	IBA	J:265628
Biological Process	GO:0032481	positive regulation of type I interferon production	IDA	J:243562
Biological Process	GO:0032481	positive regulation of type I interferon production	IDA	J:243386
Biological Process	GO:0032481	positive regulation of type I interferon production	ISO	J:164563
Biological Process	GO:0032481	positive regulation of type I interferon production	IDA	J:243563
Biological Process	GO:0032481	positive regulation of type I interferon production	IBA	J:265628
Biological Process	GO:0050776	regulation of immune response	IGI	J:226998
Biological Process	GO:0002637	regulation of immunoglobulin production	IGI	J:226998
Biological Process	GO:0045088	regulation of innate immune response	ISO	J:164563
Biological Process	GO:0050863	regulation of T cell activation	IGI	J:226998
Biological Process	GO:0032479	regulation of type I interferon production	IGI	J:226998